Confirmed speakers

• Pr Alexandre Carpentier, Paris VI Sorbonne University - FR
• Pr Steven Freear, University of Leeds - UK
• Pr Pintong Huang, Zhejiang University School of Medicine - CN
• Pr Eitan Kimmel, Technion - IL
• Dr Spiros Kotopoulis, Haukeland University Hospital - NO
• Pr Nobuki Kudo, Hokkaido University - JP
• Pr Frédéric Patat, University François-Rabelais of Tours - FR
• Pr Albert Poortinga, Eindhoven University of Technology- NL
• Dr Paul Prentice, University of Glasgow, UK
• Dr Annemieke Van Wamel, Norwegian University of Science and Technology - NO

Programme

Monday October 23th 2017

• 08h30    Welcome coffee & registration

• 09h00    Introduction

Session 1 : Sonochemotherapy

Chairmen : Pr Michiel Postema & Dr Annemieke Van Wamel

• 09h20    Pr Pintong Huang - Antitumor efficacy of ultrasonic cavitation with a drug loaded microbubbles targeting tumor angiogenesis in a fluorescent human colon cancer mouse model

• 09h40    Dr Jean-Michel Escoffre - Delivery of cetuximab to colorectal cancer using microbubble-assisted ultrasound

• 10h00    Dr Diane Bressand - In vitro and in vivo evaluation of delivery of Nab-Paclitaxel in pancreatic

  tumors with sonoporation

• 10h20    Dr Spiros Kotopoulis - Low-intensity sonoporation from lab to patient bedside: What do we know and where do we go from here?

• 10h40    Coffee break & demo Precision Accoustics

Session 2 : Bubble imaging

Chairmen : Dr Paul Prentice & Pr Steven Wrenn

• 11h20    Pr Steven Freear - Ultrafast Plane-wave Imaging for Nonlinear Detection of Therapeutic Microbubbles
• 11h40    Pr Katrien Vanderperren - Contrast-enhanced ultrasound of the kidneys in hyperthyroid cats
• 12h00    Dr Erik Verboven - Ultrasound based dosimetry for radiotherapy: in-vitro and in-vivo proof of principle
• 12h20    Lunch

Session 3 : Acoustic cluster therapy

Chairmen : Pr Katrien Vanderperren & Pr Steven Freear

• 14h00    Dr Per Sontum - Acoustic Cluster Therapy – A Novel Approach for Ultrasound Mediated Targeted Drug Delivery: Technology Basics and Proof of Concept
• 14h20    Dr Annemieke Van Wamel - Acoustic cluster therapy boosts delivery of drugs in brains and tumors
• 14h40    Dr Paul Prentice - Shocking bubbles: cavitation in focused ultrasound
• 15h00    Pr Nobuki Kudo - High-speed observation system designed for elucidating mechanisms of sonoporation
• 15h20    Coffee break

Session 4 : New insights in therapeutic bubbles

Chairmen : Dr Benoit Larrat & Pr Albert Poortinga

• 16h00    Pr Eitan Kimmel - Acoustics in Medicine in view of the intramembrane cavitation model
• 16h20    Vincent Hingot - Subwavelength far-field ultrasound targeted drug-delivery
• 16h40    Dr Bjoern Gerold - Controlling cavitation in focused ultrasound surgery: efficiency and safety

• 18h30    Public Lecture in French, Pr Frédéric Patat - Détecter, voir et soigner : des ultrasons aux multiples facettes
• 20h00    Social Dinner at Le Mastroquet

Tuesday October 24th 2017

• 08h30    Welcome coffee & registration

Session 5 : Bubbles, antibubbles, droplets

Chairmen : Dr Christine Contino-Pépin & Dr Charles Sennoga

• 09:00    Pr Albert Poortinga - Antibubbles: a new kind of acoustic bubble
• 09:20    Pr Steven Wrenn - Voltage-Activated Ultrasound Contrast Agent for Myocardial Perfusion Imaging
• 09:40    Dr Stéphane Desgranges - Stable formulations of perfluorocarbon droplets for tumor detection and treatment
• 10:00    Dr Sigrid Berg - Nanoparticle-stabilized microbubbles and ultrasound for enhanced drug delivery
• 10:20    Coffee break & demo Precision Accoustics

Session 6 : BBB

Chairmen : Pr Pintong Huang & Dr Jean-Michel Escoffre

• 11:00    Pr Alexandre Carpentier - low intensity pulsed ultrasound (LIPU) to disrupt the blood-brain barrier (BBB) followed by intravenous carboplatin chemotherapy in patients with recurrent brain tumors
• 11:20    Dr Benoit Larrat - MRI guided ultrasound-mediated blood-brain barrier opening in non-human primates using passive cavitation detection feedback control
• 11:40    Dr Barbara Cerroni - Targeting Tumour Brain Vasculature with RGD decorated Microbubbles
• 12:00    Lunch
• 14:00    CMER (Cellule Mutualisée Europe Recherche) Presentation of funding opportunities in the EU Horizon 2020 Framework Programme
• 14:20    Posters session

Session 7 : Bubble dynamics

Chairmen : Pr Nobuki Kudo & Pr Eitan Kimmel

• 15:00    Dr Alexander Doinikov - Dynamics of bubbles in a confined space
• 15:20    Kristoffer Johansen - A comparison of single-bubble and cloud models for non-stable cavitation and the emissions generated
• 15:40    Dr Mounir Tarek - Generation and outcome of reactive oxygen species produced by ultrasound stimulated micro-bubbles: Unraveling a potential mechanism of sonoporation using Molecular Simulations
• 16:00    Dr Claude Inserra - Nonspherical oscillations of gas microbubbles: threshold, dynamics and nonlinearity
• 16:20    Conclusion