Acoustic bubbles in therapy: recent advances with medical microbubbles, clouds and harmonic antibubbles

October 23, 2017 - October 24, 2017

Conference

Hôtel de Ville de Tours
Place Jean Jaurès
37000 Tours
France

Presentation

LE STUDIUM Loire Valley Institute for Advanced Studies and Inserm Research unit U930: Imaging and Brain at François Rabelais University of Tours are organising an international conference on acoustic bubbles in therapy.

Although the use of microbubbles has become common in ultrasound diagnostics, they are not that often seen in therapeutic applications. This conference focusses on recent advances in the development and application of microbubbles in therapy.

Plenary sessions include the following topics: bubble physics, bubble physical phenomena, bubble engineering and design, in-vitro evaluation, preclinical validations, and clinical studies.

Convenors

Pr Michiel Postema, LE STUDIUM / Marie Skłodowska-Curie Research Fellow
FROM University of the Witwatersrand, Johannesburg - ZA
IN RESIDENCE AT Imagerie et Cerveau (Imaging and Brain) - UMR Inserm U930 - University François-Rabelais of Tours - FR
Dr Ayache Bouakaz
Imagerie et Cerveau (Imaging and Brain) - UMR Inserm U930 - University François-Rabelais of Tours - FR

Key topics

Microbubbles, ultrasound contrast agents, bubbles clouds, antibubbles, sonoporation, ultrasound-guided drug delivery, microfluidics.

Pricing

Private institution	250 EUR
Public institution	180 EUR
Students & PhD Scholars	75 EUR
Social dinner	60 EUR

Confirmed speakers

Pr Alexandre Carpentier, Paris VI Sorbonne University - FR
Pr Steven Freear, University of Leeds - UK
Pr Pintong Huang, Zhejiang University School of Medicine - CN
Pr Eitan Kimmel, Technion - IL
Dr Spiros Kotopoulis, Haukeland University Hospital - NO
Pr Nobuki Kudo, Hokkaido University - JP
Pr Frédéric Patat, University François-Rabelais of Tours - FR
Pr Albert Poortinga, Eindhoven University of Technology- NL
Dr Paul Prentice, University of Glasgow, UK
Dr Annemieke Van Wamel, Norwegian University of Science and Technology - NO

Programme

Monday October 23th 2017

08h30 Welcome coffee & registration
09h00 Introduction

Session 1 : Sonochemotherapy

Chairmen : Pr Michiel Postema & Dr Annemieke Van Wamel

09h20 Pr Pintong Huang - Antitumor efficacy of ultrasonic cavitation with a drug loaded microbubbles targeting tumor angiogenesis in a fluorescent human colon cancer mouse model
09h40 Dr Jean-Michel Escoffre - Delivery of cetuximab to colorectal cancer using microbubble-assisted ultrasound
10h00 Dr Diane Bressand - In vitro and in vivo evaluation of delivery of Nab-Paclitaxel in pancreatic

tumors with sonoporation
10h20 Dr Spiros Kotopoulis - Low-intensity sonoporation from lab to patient bedside: What do we know and where do we go from here?
10h40 Coffee break & demo Precision Accoustics

Session 2 : Bubble imaging

Chairmen : Dr Paul Prentice & Pr Steven Wrenn

11h20 Pr Steven Freear - Ultrafast Plane-wave Imaging for Nonlinear Detection of Therapeutic Microbubbles
11h40 Pr Katrien Vanderperren - Contrast-enhanced ultrasound of the kidneys in hyperthyroid cats
12h00 Dr Erik Verboven - Ultrasound based dosimetry for radiotherapy: in-vitro and in-vivo proof of principle
12h20 Lunch

Session 3 : Acoustic cluster therapy

Chairmen : Pr Katrien Vanderperren & Pr Steven Freear

14h00 Dr Per Sontum - Acoustic Cluster Therapy – A Novel Approach for Ultrasound Mediated Targeted Drug Delivery: Technology Basics and Proof of Concept
14h20 Dr Annemieke Van Wamel - Acoustic cluster therapy boosts delivery of drugs in brains and tumors
14h40 Dr Paul Prentice - Shocking bubbles: cavitation in focused ultrasound
15h00 Pr Nobuki Kudo - High-speed observation system designed for elucidating mechanisms of sonoporation
15h20 Coffee break

Session 4 : New insights in therapeutic bubbles

Chairmen : Dr Benoit Larrat & Pr Albert Poortinga

16h00 Pr Eitan Kimmel - Acoustics in Medicine in view of the intramembrane cavitation model
16h20 Vincent Hingot - Subwavelength far-field ultrasound targeted drug-delivery
16h40 Dr Bjoern Gerold - Controlling cavitation in focused ultrasound surgery: efficiency and safety

18h30 Public Lecture in French, Pr Frédéric Patat - Détecter, voir et soigner : des ultrasons aux multiples facettes
20h00 Social Dinner at Le Mastroquet

Tuesday October 24th 2017

08h30 Welcome coffee & registration

Session 5 : Bubbles, antibubbles, droplets

Chairmen : Dr Christine Contino-Pépin & Dr Charles Sennoga

09:00 Pr Albert Poortinga - Antibubbles: a new kind of acoustic bubble
09:20 Pr Steven Wrenn - Voltage-Activated Ultrasound Contrast Agent for Myocardial Perfusion Imaging
09:40 Dr Stéphane Desgranges - Stable formulations of perfluorocarbon droplets for tumor detection and treatment
10:00 Dr Sigrid Berg - Nanoparticle-stabilized microbubbles and ultrasound for enhanced drug delivery
10:20 Coffee break & demo Precision Accoustics

Session 6 : BBB

Chairmen : Pr Pintong Huang & Dr Jean-Michel Escoffre

11:00 Pr Alexandre Carpentier - low intensity pulsed ultrasound (LIPU) to disrupt the blood-brain barrier (BBB) followed by intravenous carboplatin chemotherapy in patients with recurrent brain tumors
11:20 Dr Benoit Larrat - MRI guided ultrasound-mediated blood-brain barrier opening in non-human primates using passive cavitation detection feedback control
11:40 Dr Barbara Cerroni - Targeting Tumour Brain Vasculature with RGD decorated Microbubbles
12:00 Lunch
14:00 CMER (Cellule Mutualisée Europe Recherche) Presentation of funding opportunities in the EU Horizon 2020 Framework Programme
14:20 Posters session

Session 7 : Bubble dynamics

Chairmen : Pr Nobuki Kudo & Pr Eitan Kimmel

15:00 Dr Alexander Doinikov - Dynamics of bubbles in a confined space
15:20 Kristoffer Johansen - A comparison of single-bubble and cloud models for non-stable cavitation and the emissions generated
15:40 Dr Mounir Tarek - Generation and outcome of reactive oxygen species produced by ultrasound stimulated micro-bubbles: Unraveling a potential mechanism of sonoporation using Molecular Simulations
16:00 Dr Claude Inserra - Nonspherical oscillations of gas microbubbles: threshold, dynamics and nonlinearity
16:20 Conclusion