Acoustic bubbles in therapy: recent advances with medical microbubbles, clouds and harmonic antibubbles

October 23, 2017 - October 24, 2017

Hôtel de Ville de Tours
Place Jean Jaurès
37000 Tours


LE STUDIUM Loire Valley Institute for Advanced Studies and Inserm Research unit U930: Imaging and Brain at François Rabelais University of Tours are organising an international conference on acoustic bubbles in therapy.

Although the use of microbubbles has become common in ultrasound diagnostics, they are not that often seen in therapeutic applications. This conference focusses on recent advances in the development and application of microbubbles in therapy.

Plenary sessions include the following topics: bubble physics, bubble physical phenomena, bubble engineering and design, in-vitro evaluation, preclinical validations, and clinical studies.


  • Pr Michiel Postema, LE STUDIUM / Marie Skłodowska-Curie Research Fellow
    FROM University of the Witwatersrand, Johannesburg - ZA
    IN RESIDENCE AT Imagerie et Cerveau (Imaging and Brain) - UMR Inserm U930 - University François-Rabelais of Tours - FR
  • Dr Ayache Bouakaz
    Imagerie et Cerveau (Imaging and Brain) - UMR Inserm U930 - University François-Rabelais of Tours - FR


Key topics

Microbubbles, ultrasound contrast agents, bubbles clouds, antibubbles, sonoporation, ultrasound-guided drug delivery, microfluidics.



    Private institution 250 EUR
    Public institution 180 EUR
    Students & PhD Scholars 75 EUR
    Social dinner 60 EUR

    Confirmed speakers

    • Pr Alexandre Carpentier, Paris VI Sorbonne University - FR
    • Pr Steven Freear, University of Leeds - UK
    • Pr Pintong Huang, Zhejiang University School of Medicine - CN
    • Pr Eitan Kimmel, Technion - IL
    • Dr Spiros Kotopoulis, Haukeland University Hospital - NO
    • Pr Nobuki Kudo, Hokkaido University - JP
    • Pr Frédéric Patat, University François-Rabelais of Tours - FR
    • Pr Albert Poortinga, Eindhoven University of Technology- NL
    • Dr Paul Prentice, University of Glasgow, UK
    • Dr Annemieke Van Wamel, Norwegian University of Science and Technology - NO


    Monday October 23th 2017

    • 08h30    Welcome coffee & registration

    • 09h00    Introduction

    Session 1 : Sonochemotherapy

    Chairmen : Pr Michiel Postema & Dr Annemieke Van Wamel

    • 09h20    Pr Pintong Huang - Antitumor efficacy of ultrasonic cavitation with a drug loaded microbubbles targeting tumor angiogenesis in a fluorescent human colon cancer mouse model

    • 09h40    Dr Jean-Michel Escoffre - Delivery of cetuximab to colorectal cancer using microbubble-assisted ultrasound

    • 10h00    Dr Diane Bressand - In vitro and in vivo evaluation of delivery of Nab-Paclitaxel in pancreatic

      tumors with sonoporation

    • 10h20    Dr Spiros Kotopoulis - Low-intensity sonoporation from lab to patient bedside: What do we know and where do we go from here?

    • 10h40    Coffee break & demo Precision Accoustics

    Session 2 : Bubble imaging

    Chairmen : Dr Paul Prentice & Pr Steven Wrenn

    • 11h20    Pr Steven Freear - Ultrafast Plane-wave Imaging for Nonlinear Detection of Therapeutic Microbubbles
    • 11h40    Pr Katrien Vanderperren - Contrast-enhanced ultrasound of the kidneys in hyperthyroid cats
    • 12h00    Dr Erik Verboven - Ultrasound based dosimetry for radiotherapy: in-vitro and in-vivo proof of principle
    • 12h20    Lunch

    Session 3 : Acoustic cluster therapy

    Chairmen : Pr Katrien Vanderperren & Pr Steven Freear

    • 14h00    Dr Per Sontum - Acoustic Cluster Therapy – A Novel Approach for Ultrasound Mediated Targeted Drug Delivery: Technology Basics and Proof of Concept
    • 14h20    Dr Annemieke Van Wamel - Acoustic cluster therapy boosts delivery of drugs in brains and tumors
    • 14h40    Dr Paul Prentice - Shocking bubbles: cavitation in focused ultrasound
    • 15h00    Pr Nobuki Kudo - High-speed observation system designed for elucidating mechanisms of sonoporation
    • 15h20    Coffee break

    Session 4 : New insights in therapeutic bubbles

    Chairmen : Dr Benoit Larrat & Pr Albert Poortinga

    • 16h00    Pr Eitan Kimmel - Acoustics in Medicine in view of the intramembrane cavitation model
    • 16h20    Vincent Hingot - Subwavelength far-field ultrasound targeted drug-delivery
    • 16h40    Dr Bjoern Gerold - Controlling cavitation in focused ultrasound surgery: efficiency and safety


    • 18h30    Public Lecture in French, Pr Frédéric Patat - Détecter, voir et soigner : des ultrasons aux multiples facettes
    • 20h00    Social Dinner at Le Mastroquet

    Tuesday October 24th 2017

    • 08h30    Welcome coffee & registration

    Session 5 : Bubbles, antibubbles, droplets

    Chairmen : Dr Christine Contino-Pépin & Dr Charles Sennoga

    • 09:00    Pr Albert Poortinga - Antibubbles: a new kind of acoustic bubble
    • 09:20    Pr Steven Wrenn - Voltage-Activated Ultrasound Contrast Agent for Myocardial Perfusion Imaging
    • 09:40    Dr Stéphane Desgranges - Stable formulations of perfluorocarbon droplets for tumor detection and treatment
    • 10:00    Dr Sigrid Berg - Nanoparticle-stabilized microbubbles and ultrasound for enhanced drug delivery
    • 10:20    Coffee break & demo Precision Accoustics

    Session 6 : BBB

    Chairmen : Pr Pintong Huang & Dr Jean-Michel Escoffre

    • 11:00    Pr Alexandre Carpentier - low intensity pulsed ultrasound (LIPU) to disrupt the blood-brain barrier (BBB) followed by intravenous carboplatin chemotherapy in patients with recurrent brain tumors
    • 11:20    Dr Benoit Larrat - MRI guided ultrasound-mediated blood-brain barrier opening in non-human primates using passive cavitation detection feedback control
    • 11:40    Dr Barbara Cerroni - Targeting Tumour Brain Vasculature with RGD decorated Microbubbles
    • 12:00    Lunch
    • 14:00    CMER (Cellule Mutualisée Europe Recherche) Presentation of funding opportunities in the EU Horizon 2020 Framework Programme
    • 14:20    Posters session

    Session 7 : Bubble dynamics

    Chairmen : Pr Nobuki Kudo & Pr Eitan Kimmel

    • 15:00    Dr Alexander Doinikov - Dynamics of bubbles in a confined space
    • 15:20    Kristoffer Johansen - A comparison of single-bubble and cloud models for non-stable cavitation and the emissions generated
    • 15:40    Dr Mounir Tarek - Generation and outcome of reactive oxygen species produced by ultrasound stimulated micro-bubbles: Unraveling a potential mechanism of sonoporation using Molecular Simulations
    • 16:00    Dr Claude Inserra - Nonspherical oscillations of gas microbubbles: threshold, dynamics and nonlinearity
    • 16:20    Conclusion

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