Synthesis and Isolation of Bio-Active Molecules (SIMBA)

The themes of SIMBA focus on the discovery and synthesis of small molecules for therapeutic purposes in oncology and infectiology, derived from synthetic chemistry or plant/microalgae extracts. Two main axes guide our research: the first axis explores the synthesis or isolation of natural bioactive compounds, promoting the development of new synthetic pathways and ecological extraction processes. The second axis evaluates the biological properties of selected molecules, in collaboration with specialized teams in infectiology, oncology, and cosmetology.

Research topics:

• Design and novel molecular structures of interest: development of methodologies in heterocyclic chemistry and fluorine chemistry; applications/interfaces with biology & health.
• Green solvents for sustainable development: design, characterization, innovation in extractive sciences and synthesis, and applications

Equipment and technology:

• X-ray Single crystal diffraction 
• X-ray Powder diffraction
• DAD HPLC chains, HPTLC-densitometry, GC-FID 
• PLC-MS chain 
• RX Fluorescence 
• Centrifugal Partition Chromatography (CPC) 
• Synthesis microwave 
• Microplate reader 
• Combiflash purification system 
• TRA IR spectrometer 
• SINAPTEC ultrasonic extractor and probe
• Smart DAC 400 Haushild