Membrane Signalling and Inflammation in reperfusion injuries (ISCHEMIA)
© UnivTours
Transplantation, Immunologie et Inflammation
Address
EA4245, Bâtiment Vialle - Etages 1 et 2
Faculté de Médecine de Tours, 10 Boulevard Tonnellé
Tours 37032
France
Director
Sébastien Roger
Contact
seccdg@univ-tours.fr
Website
Scientific Field
The research unit studies the interactions between cells of the stressed tissue/organ (cardiac cells, normal and cancer epithelial cancer cells) and immune cells, with the objective of modulating immuno-inflammatory responses in hypoxia/ ischemia, by developing new strategies using pharmacological drugs and antibodies targeting ion channels and purinoreceptors.
Research topics: immunology and inflammation in organ transplantation and ischemia reperfusion
Skills and expertise:
- Cell culture (human dendritic cells, cardiomyocytes, fibroblasts, renal tubular cells, endothelial cells, normal and cancer epithelial mammary and colorectal cells)
- Cultures in hypoxic conditions
- B cell immortalization
- Cell phenotyping
- Cellular electrophysiology
- Bio-clinical studies in transplant patients
Equipment and technology:
- Cell sorting
- RT-qPCR
- Western blotting
- ELISA
- Hypoxic chamber
- Cell culture equipment
- Patch clamp
- Spectrofluorimetry
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