Prof. Georg von Samson-Himmelstjerna

Scientific Field
October, 2019 - March, 2020



Free University of Berlin - DE

In residence at

Infectiology and Public Health (ISP) / Centre INRAE Val de Loire, University of Tours - FR

Host scientist

Dr Cédric Neveu 

Events organised by this fellow

Publications in relation with the research project

Final reports

Georg von Samson-Himmelstjerna
Alexander P. Gerhard
Jürgen Krücken
Claude L. Charvet
Cedric Neveu
Abdallah Harmache
Download PDF Link to the publication

Infections with parasitic helminths expose serious health threats to humans and animals alike. Prevention of disease is dependent on the effective treatment using anthelmintics. Unfortunately, anthelmintic resistance (AR) has evolved in many helminth species during the past decades and meanwhile poses a major constraint to established worm control approaches. This project aimed to improve our understanding of the molecular mechanisms by which helminths, particularly the potentially deadly horse parasite Parascaris sp., become capable of withstanding drug treatment. To this end, Parascaris P-glycoproteins (Pgp), belonging to an important group of mediators of anthelmintic resistance, were introduced into the model organism Caenorhabditis elegans using the CRISPR/Cas9 technology. The resulting transgenic lines will subsequently be analyzed to functionally elucidate the role of putatively AR-associated Parascaris Pgp sequence polymorphisms.