July Andrea Galeano Zea

From

Metropolitan Technological Institute - CO

In residence at

PRISME Laboratory / University of Orléans, INSA CVL - FR

Host scientist

Sylvie Treuillet

PROJECT

Light-tissue interaction model for the assessment of skin aging in cosmetics using LC-OCT

Understanding skin aging is of both scientific and industrial interest due to its social, psychological, and medical implications. Negative perceptions associated with skin aging may lead to social isolation or discrimination. Moreover, biological processes such as cellular senescence and the decline of skin physiological functions are closely linked to the development of pathologies, including psoriasis and skin cancer. In this context, the development of new tools to better understand these biological mechanisms is essential to improve therapeutic strategies and skincare routines, thereby contributing to healthier skin and an improved quality of life.
Line-field confocal optical coherence tomography (LC-OCT) is a state-of-the-art imaging technique that enables in vivo access to the biological structures of skin layers with a resolution of approximately 1 micron. This project aims to develop a computational tool to estimate scattering coefficients based on a light–tissue interaction model, in order to extend current research on the optical properties of LC-OCT images of biological tissues.
Direct access to a large dataset of LC-OCT images of healthy skin, obtained from a multiethnic panel of women aged 20 to 70 years, will make it possible to develop a reliable light–tissue interaction model and to identify optical coefficients significantly associated with the degradation of skin biological structures, with potential applications in disease diagnosis and the evaluation of skincare products.