The role of glycosylation on serpin biology and conformational disease

September 27, 2017 - September 29, 2017

Hôtel Dupanloup
1 rue Dupanloup
45000 Orléans


The registration is closed !

The aim of the conference is to bring together scientists working on the molecular aspects of protein conformational disease, specifically on serpinopathies, and on the role of glycosylation on the folding, stability, function and cellular fate of serpin proteins. Although this topic is recognised as an important aspect in the field, it has not been the focus of a dedicated conference so far. This event aims to be a milestone in the broader topic of the role of glycosylation on conformational disease, devoting a substantial time to open discussion with the intention of fostering collaborations and promoting new ideas.

  Immunoshape Session

Glycoscience, which focuses on the study of the structural and functional roles of carbohydrates in their biological context, has an increasing impact on many areas such as biotechnology, health, food and energy. IMMUNOSHAPE is a Marie Curie European Training Network that provides multidisciplinary and multisectorial training in biomedical glycoscience and its industrial applications to a new generation of young scientists. The training  course on  Intellectual property strategy and applications in life sciences will be on the morning of September 27th and is open to all the participants of the LE STUDIUM Conference on The role of glycosylation on serpin biology and conformational disease.

Please specify your interest in attending this training session in your registration form. Registration to the session is free but mandatory.



  • Dr Mauro Manno, LE STUDIUM / Marie Skłodowska-Curie Research Fellow.
    FROM: CNR Institute of Biophysics, Palermo, IT
    Institute of Organic and Analytical Chemistry (ICOA) - University of Orléans/CNRS - Orléans - FR
  • Pr Richard Daniellou
    Institute of Organic and Analytical Chemistry (ICOA) - University of Orléans/CNRS - Orléans - FR 


The role of glycosylation on serpin biology and conformational disease



  • Pr Richard Daniellou, University  of Orléans - FR
  • Dr Mauro Manno, CNR Institute of Biophysics at Palermo - IT
  • Dr Maria Elena Miranda Banos, Sapienza Univ. of Rome - IT


Glycosylation, serpins, serpinopathies, protein conformational disease, protein folding and misfolding, protein traffickig


Abstracts, Bio & Posters must be written in English. 

Abstract are requested for oral and poster presentations focused on specific topic area including glycosylation, serpins, serpinopathies, protein conformational disease, protein folding and misfolding, protein trafficking.

Abstract are limited to 250 words, and should be submitted via email to Maurine Villiers

Due date Friday 18th August 2017 for oral presentations & posters.

Conference PROGRAM

Wednesday September 27th 2017

Immunoshape session

  • 09h00   IP Lecture by William Hammond (French Patent Attorney)
  • 10h30   Coffee break
  • 10h45   IP Case studies by William Hammond (French Patent Attorney)
  • 12h30    Welcome lunch & registration

Opening session

  • 14h00   Opening
  • 14h30   H2020 funding opportunities, Thomas Rochette-Castel (Cellule Mutualisée Europe Recherche - CMER)
  • 15h00   Pr Marco Cicardi - SERPING1 mutations, a serpinopathy leading to recurrent angioedema
  • 15h30   Coffee break

Session 1: Glycosylation and its clinical implication in Serpinopathies

  • 16h00   Pr Philippe Delannoy - Protein glycosylation: nature, biosynthesis and disease implications
  • 16h30   Pr Javier Corral - Glycosylation of antithrombin: data from patient
  • 17h00   Pr Markus Glatzel - Insights into the pathophysiology of Familial Encephalopathy with Neuroserpin Inclusion Bodies using murine models
  • 17h45   Orléans city center guided visit
  • 19h15   Wine & cheese cocktail at Hôtel Dupanloup

Thursday September 28th 2017

Session 2: Neuroserpin: function, dysfunction, therapy

  • 08h30   Welcome coffee
  • 09h00   Pr Denis Vivien - Single chain tPA versus two chain tPA from fibrinolysis to neuronal signaling
  • 09h30   Dr Giovanna Galliciotti - Neuroserpin in nervous system development, manteinance and degeneration
  • 10h00   Pr Stefano Ricagno - Effects of embelin in neuroserpin polymerisation
  • 10h30   Coffee break & posters session

Session 3: ER: Stress, accumulation, clearance

  • 10h50   Pr Stefan Marciniak - Measuring ER viscosity: relevance to alpha-1 antitrypsin deficiency
  • 11h20   Dr Benoit Roussel - Non-proteolytic roles for the serine protease tPA in the ischemic brain: interactions and modifications on the ER stress and autophagic pathways
  • 11h50   Ilaria Fregno - Clearance of proteosome-resistant protein polymers from the mammalian ER
  • 12h10   Dr Riccardo Ronzoni - Kinetics of Z α1-antitrypsin polymers: intracellular accumulation and secretion
  • 12h30   Lunch

Session  4: Glycosylation and its biological implication in Serpinopathies

  • 14h00   Dr Maria Elena Miranda Banos - Neuroserpin polymers from the cell biology perspective: effects of N-glycosylation and induction of oxidative stress in cell models of dementia FENIB
  • 14h30   Pr Bibek Gooptu - Biophysical characterisation of glycosylation and its effects in α1-antitrypsin
  • 15h00   Dr Irene Martínez Martínez - Study of the antithrombin folding using the N-glycosylation as a tool
  • 15h30   Dr María Eugenia de la Morena-Barrio - Defects of N-glycosylation on antithrombin
  • 15h50   Coffee break

Session  5: Post-translational heterogeneity 

  • 16h10   Dr Sonia Caccia - C1-Inhibitor, The Heavy Serpin
  • 16h40   Pr Anna Fra - Uncommon behaviour of rare Alpha-1 Antitrypsin variants
  • 17h10   Mattia Laffranchi - Hetero-polymerization of Z AAT with other alpha1-antitrypsin variants in cellular models
  • 17h30   Jihen Ati - Glycosylate me, LEXSY !
  • 17h50   Open session and discussion on Networking
  • 20h15   Social Dinner

Friday September 29th 2017

Session  6: Polymers: pathways, structures

  • 08h30   Welcome coffee
  • 09h10   Dr Mauro Manno - The well-tempered polymerisation of neuroserpin: a biophysical perspective
  • 09h40   Dr James Irving - Tools for probing the alpha-1-antitrypsin polymerisation pathway
  • 10h10   Dr Vincenzo Martorana  - Can SAXS experiments help in elucidating the structure of serpin protein polymers?
  • 10h50   Coffee break

Closing Session

  • 11h10   Pr David A. Lomas - Therapeutic strategies for antitrypsin deficiency 
  • 11h40   Closing remarks




Registration has to be completed before the meeting and upon abstract acceptance by sending email to Maurine Villiers.

Registration fees include: conference participation, welcome cocktail on 27/09, light lunch on 28/09, coffee breaks.

Private institutions250 EUR
Researchers180 EUR
Students60 EUR
Social dinner60 EUR

Partners of the event