Is Multimodal Imaging an Invention with a Future? The Input of Chemistry

December 11, 2017 - December 13, 2017

Conference

Hôtel Dupanloup
1 rue Dupanloup
45000 Orléans
France

Presentation

The scientific concept of multimodal imaging has been gaining momentum over the last decades. Given the intrinsic physical properties of each imaging technique available in the current clinical practice (MRI, CT, US, PET/SPECT or optical imaging), it is clear that none of these modalities alone is able to address all the questions in the search for a correct diagnosis or therapeutic follow-up. Today, many leading instrumental companies, supported by the physicists from academia, are investing in the design/improvement of multimodal scanners (e.g. PET-MRI). In parallel, chemists working in the field of imaging worldwide are gathering their efforts to create agents that combine various imaging reporters in a single probe.

This conference, jointly organized by LE STUDIUM Loire Valley Institute for Advanced Studies and the Centre for Molecular Biophysics - CNRS Orléans, will address the questions whether multimodal imaging is an invention with future and how chemists can contribute to its success. The conference will have a special focus on metal-based probes and MRI, optical and nuclear imaging modalities.

The conference will start on 11th of December with a welcome lunch (12H00) and finish on 13th of December at 12H30.

Convenors

Dr Kristina Djanashvili, LE STUDIUM / Marie Skłodowska-Curie Research Fellow
FROM Department of Biotechnology, Delft University of Technology - NL
IN RESIDENCE AT Molecular Biophysics Center (CBM) / CNRS - Orléans - FR
Dr Éva Jakab Tóth
Molecular Biophysics Center (CBM) / CNRS - Orléans - FR

Slideshow

Topics

Multimodal imaging probes incl. nanoparticles and small metal complexes
Combination of imaging and therapy
Responsive probes
Validation of output in MRI, nuclear and optical imaging techniques

Special honorary symposium

We take the opportunity of this Le Studium conference to honor Pr Carlos F.G.C. Geraldes (University of Coimbra, Portugal) and Pr Lothar Helm (Ecole Polytechnique Fédérale de Lausanne, Switzerland) and celebrate their outstanding scientific carrier during a dedicated session – “40 years in Lanthanide Chemistry”.

Carlos Geraldes and Lothar Helm have made an immense contribution to the understanding and development of paramagnetic probes for Magnetic Resonance Imaging. Through a very active participation in successive European COST Actions related to metals in medical imaging, their work hasled to novel, fundamental insights into the physical-chemical behavior of lanthanide-complexes in general and the paramagnetic relaxation theory of contrast agents in particular.
Today, Pr Lothar Helm is retiring from the position of titular professor and director of the NMR service of the Institute of Chemical Sciences and Engineering at EPFL, Lausanne (CH), while Pr Carlos Geraldes is leaving the post of full professor of Structural Biochemistry at the Department of Life Sciences of the University of Coimbra (PT). In this symposium, the guest speakers will overview the state of the art in the field of MR imaging agents and discuss future perspectives.

Confirmed Speakers

Pr Carlos F.G.C. Geraldes - University of Coimbra - PT
Pr Lothar Helm - École Polytechnique Fédérale de Lausanne - CH
Pr Silvio Aime - University of Torino - IT
Pr Robert N. Muller - University of Mons - BE
Pr Peter Caravan - Harvard Medical School and Massachusetts General Hospital - US
Pr David Parker - Durham University - UK
Pr Jean-Philippe Pignol - Erasmus MC Cancer Institute - NL
Pr Lorenzo Tei - University of Piemonte Orientale "Amedeo Avogadro" - IT
Pr Carlos Platas-Iglesias - University of A Coruña - ES
Dr Gyula Tircso - University of Debrecen - HU
Dr Penelope Bouziotis - National Center for Scientific Research "Demokritos" - GR
Pr Nicholas Long - Imperial College London - UK
Dr Rafael T. M. de Rosales - King’s College London - UK
Dr François Lux - University of Claude Bernard Lyon - FR
Dr Victor Goncalves - University of Bourgogne - FR
Dr Nathalie Mignet - University of Paris Descartes - FR
Dr Rainer Kneuer - Novartis - CH
Dr Joop A. Peters - Delft University of Technology - NL

Posters

Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes.

Location

Hôtel Dupanloup : 1, rue Dupanloup - 45000 ORLEANS - FR

The conference venue is unique. Located right next to the Orléans’ cathedral, the episcopal palace of Orléans, built between 1635 and 1641, locally known as the Hôtel Dupanloup, is a classical French building which served until 1905 of residence to the bishops of Orléans. Since 2014, the renewed palace hosts the International University Center for Research and Le Studium Loire Valley Institute for Advanced Studies.

Participants will be welcomed in this exceptional surrounding, blending Middle Age and Renaissance cultures with modern design and will have the opportunity to discover French cuisine and wines.

Practical Informations

Conference PROGRAM

Monday December 11^th2017

12h30 Registration & Welcome Lunch
14h00 Welcome & Opening
14h10 Scientific opening by Éva Jakab Tóth
14h20 Dr Kristina Djanashvili - Towards Multimodal Imaging with Porous Nanodevices
14h50 Pr Lorenzo Tei - Exploring mesoporous silica nanoparticles as multimodal imaging and theranostic probes
15h20 Dr Rainer Kneuer - Multimodality & Multiscale Imaging of Biologics and Nanomaterials
15h50 Dr Ivana Martinic - Near-Infrared Optical Imaging with Lanthanide-Based Molecules, Macromolecules and Nanomaterials
16h10 Coffee Break
16h40 Pr Jean-Philippe Pignol - Nanoparticle image guided ablation therapy for early breast cancers
17h10 Dr François Lux - AGuIX, a gadolinium based ultrasmall nanoparticle: translation to the clinic
17h40 Dr Aline Nonat - Photonic upconversion in solution with self-assembled lanthanide complexes
18h30 Dr Natalie Mignet - Les Nanotechnologies au Service de la Santé (Public Lecture in French)
20h00 Wine & Cheese Cocktail

Tuesday December 12^th2017

08h45 Welcome coffee
09h00 Pr Nicholas J. Long - Functionalised Microbubbles: For Ultrasound and PET Cancer Imaging
09h30 Enikő Molnár - Tuning the physicochemical parameters of Gd(III) complexes by rigidifying the ligand backbone: synthesis and coordination properties of the CHX-DTPA and PhDTPA ligands
09h50 Dr Ka-Leung Wong - Lanthanide complexes for cancer imaging and treatment
10h10 Coffee break
10h30 Posters session
11h10 Dr Penelope Bouziotis - Molecular Platforms as Probes for Dual-Modality Imaging
11h40 Dr Sara Pinto - New Biocompatible Redox Probe Based on a Mn(II)Mn(III) Porphyrin: Synthesis and Physical - Chemical Characterization
12h00 Lunch

Special Honorary Symposium - Pr Carlos GERALDES and Pr Lothar HELM - 40 years of Lanthanide Chemistry

13h30 Pr Robert N. Muller - Once upon a time, a NMR picture appeared …
14h00 Pr Peter Caravan - Applications of multimodal molecular imaging in fibrotic diseases
14h30 Dr Gyula Tircso - Mn²⁺ complexes as Contrast Agents for Magnetic Resonance Imaging: are we there yet?
15h00 Dr Carlos Platas-Iglesias - Rational control of key physicochemical parameters of T₁ and CEST Ln(III)-based MRI agents
15h30 Coffee break
16h15 Pr Silvio Aime - The issue of Gadolinium retained in tissues upon administration of MRI contrast agents
16h45 Pr David Parker - Triple Proton Imaging: the theory and the practice
17h15 Pr Joop A. Peters - Lanthanide research networks with Carlos Geraldes and Lothar Helm
17h30 Pr Carlos Geraldes - A personal experience on Lanthanides as NMR structural and imaging probes
18h00 Pr Lothar Helm - MRI contrast agents and fundamental research – 30 years of fruitful alliance
19h15 Departure to Olivet by bus
20h00 Gala dinner at the restaurant Le Pavillon Bleu

Wednesday December 13^th2017

08h45 Welcome coffee
09h00 Dr Victor Goncalves - Dual Labeling of proteins for multimodal imaging
09h30 Dr Pascale Delangle - Lanthanide-coordinating peptides as tools to study interactions with DNA
09h50 Dr Celine Henoumont - Use of the STD NMR technique to evaluate the affinity of a potential MRI contrast agent towards cancer cells
10h10 Dr Elena Ishow - Raspberry-Like Magneto-Fluorescent Nanoassemblies as Versatile Platforms for In Vitro and In Vivo Diagnostics
10h30 Coffee break
11h00 Dr Rafael T.M. de Rosales - Exploiting Multimodal Imaging for Preclinical and Clinical Nanomedicine
11h30 Dr Maryline Beyler - New pyclen based chelators for diagnostics or therapy
11h50 Dr Nathalie Mignet - Bimodal imaging to ease the development of nanomedicines
12h20 Scientific conclusions by Éva Jakab Tóth and Kristina Djanashvili
12h30 Lunch

PRICING

Private institutions	250 EUR
Academic participants	150 EUR
Students & PhD Scholars	75 EUR
Social dinner	60 EUR