The role of glycosylation on serpin biology and conformational disease
Hôtel Dupanloup
1 rue Dupanloup
45000 Orléans
France
Presentation
The registration is closed !
The aim of the conference is to bring together scientists working on the molecular aspects of protein conformational disease, specifically on serpinopathies, and on the role of glycosylation on the folding, stability, function and cellular fate of serpin proteins. Although this topic is recognised as an important aspect in the field, it has not been the focus of a dedicated conference so far. This event aims to be a milestone in the broader topic of the role of glycosylation on conformational disease, devoting a substantial time to open discussion with the intention of fostering collaborations and promoting new ideas.
Immunoshape Session
Glycoscience, which focuses on the study of the structural and functional roles of carbohydrates in their biological context, has an increasing impact on many areas such as biotechnology, health, food and energy. IMMUNOSHAPE is a Marie Curie European Training Network that provides multidisciplinary and multisectorial training in biomedical glycoscience and its industrial applications to a new generation of young scientists. The training course on Intellectual property strategy and applications in life sciences will be on the morning of September 27th and is open to all the participants of the LE STUDIUM Conference on The role of glycosylation on serpin biology and conformational disease.
Please specify your interest in attending this training session in your registration form. Registration to the session is free but mandatory.
LOCATION
CONVENORS
- Dr Mauro Manno, LE STUDIUM / Marie Skłodowska-Curie Research Fellow.
FROM: CNR Institute of Biophysics, Palermo, IT
IN RESIDENCE AT:
Institute of Organic and Analytical Chemistry (ICOA) - University of Orléans/CNRS - Orléans - FR - Pr Richard Daniellou
Institute of Organic and Analytical Chemistry (ICOA) - University of Orléans/CNRS - Orléans - FR
Slideshow
SPEAKERS
- Dr Sonia Caccia, Universityv of Milan, Milan - IT
- Pr Marco Cicardi, Ospedale Sacco/univ. Milan, Milan - IT
- Pr Javier Corral, University of Murcia - ES
- Pr Philippe Delannoy, University of Lille - FR
- Pr Anna Fra, University of Brescia - IT
- Dr Giovanna Galliciotti, University of Hamburg - DE
- Pr Markus Glatzel, University of Hamburg - DE
- Pr Bibek Gooptu, University of Leicester - UK
- Dr James I. Irving, UCL, London - UK
- Pr David A. Lomas, UCL, London - UK
- Pr Stefan Marciniak, University of Cambridge - UK
- Dr Irene Martínez Martínez, University of Murcia - ES
- Dr Vincenzo Martorana, CNR Institute of Biophysics, Palermo - IT
- Dr Maria Elena Miranda Banos, Sapienza University of Roma - IT
- Pr Stefano Ricagno, University of Milan - IT
- Dr Benoit Roussel, University of Caen - FR
- Pr Denis Vivien, University of Caen - FR
SCIENTIFIC COMMITTEE
- Pr Richard Daniellou, University of Orléans - FR
- Dr Mauro Manno, CNR Institute of Biophysics at Palermo - IT
- Dr Maria Elena Miranda Banos, Sapienza Univ. of Rome - IT
MAIN TOPICS
CALL FOR ABSTRACT
Abstracts, Bio & Posters must be written in English.
Abstract are requested for oral and poster presentations focused on specific topic area including glycosylation, serpins, serpinopathies, protein conformational disease, protein folding and misfolding, protein trafficking.
Abstract are limited to 250 words, and should be submitted via email to Maurine Villiers
Due date Friday 18th August 2017 for oral presentations & posters.
Conference PROGRAM
Wednesday September 27th 2017
Immunoshape session
IP IN PHARMACEUTICAL AND DIAGNOSTIC PRODUCT DEVELOPMENT
- 09h00 IP Lecture by William Hammond (French Patent Attorney)
- 10h30 Coffee break
- 10h45 IP Case studies by William Hammond (French Patent Attorney)
- 12h30 Welcome lunch & registration
Opening session
- 14h00 Opening
- 14h30 H2020 funding opportunities, Thomas Rochette-Castel (Cellule Mutualisée Europe Recherche - CMER)
- 15h00 Pr Marco Cicardi - SERPING1 mutations, a serpinopathy leading to recurrent angioedema
- 15h30 Coffee break
Session 1: Glycosylation and its clinical implication in Serpinopathies
- 16h00 Pr Philippe Delannoy - Protein glycosylation: nature, biosynthesis and disease implications
- 16h30 Pr Javier Corral - Glycosylation of antithrombin: data from patient
- 17h00 Pr Markus Glatzel - Insights into the pathophysiology of Familial Encephalopathy with Neuroserpin Inclusion Bodies using murine models
- 17h45 Orléans city center guided visit
- 19h15 Wine & cheese cocktail at Hôtel Dupanloup
Thursday September 28th 2017
Session 2: Neuroserpin: function, dysfunction, therapy
- 08h30 Welcome coffee
- 09h00 Pr Denis Vivien - Single chain tPA versus two chain tPA from fibrinolysis to neuronal signaling
- 09h30 Dr Giovanna Galliciotti - Neuroserpin in nervous system development, manteinance and degeneration
- 10h00 Pr Stefano Ricagno - Effects of embelin in neuroserpin polymerisation
- 10h30 Coffee break & posters session
Session 3: ER: Stress, accumulation, clearance
- 10h50 Pr Stefan Marciniak - Measuring ER viscosity: relevance to alpha-1 antitrypsin deficiency
- 11h20 Dr Benoit Roussel - Non-proteolytic roles for the serine protease tPA in the ischemic brain: interactions and modifications on the ER stress and autophagic pathways
- 11h50 Ilaria Fregno - Clearance of proteosome-resistant protein polymers from the mammalian ER
- 12h10 Dr Riccardo Ronzoni - Kinetics of Z α1-antitrypsin polymers: intracellular accumulation and secretion
- 12h30 Lunch
Session 4: Glycosylation and its biological implication in Serpinopathies
- 14h00 Dr Maria Elena Miranda Banos - Neuroserpin polymers from the cell biology perspective: effects of N-glycosylation and induction of oxidative stress in cell models of dementia FENIB
- 14h30 Pr Bibek Gooptu - Biophysical characterisation of glycosylation and its effects in α1-antitrypsin
- 15h00 Dr Irene Martínez Martínez - Study of the antithrombin folding using the N-glycosylation as a tool
- 15h30 Dr María Eugenia de la Morena-Barrio - Defects of N-glycosylation on antithrombin
- 15h50 Coffee break
Session 5: Post-translational heterogeneity
- 16h10 Dr Sonia Caccia - C1-Inhibitor, The Heavy Serpin
- 16h40 Pr Anna Fra - Uncommon behaviour of rare Alpha-1 Antitrypsin variants
- 17h10 Mattia Laffranchi - Hetero-polymerization of Z AAT with other alpha1-antitrypsin variants in cellular models
- 17h30 Jihen Ati - Glycosylate me, LEXSY !
- 17h50 Open session and discussion on Networking
- 20h15 Social Dinner
Friday September 29th 2017
Session 6: Polymers: pathways, structures
- 08h30 Welcome coffee
- 09h10 Dr Mauro Manno - The well-tempered polymerisation of neuroserpin: a biophysical perspective
- 09h40 Dr James Irving - Tools for probing the alpha-1-antitrypsin polymerisation pathway
- 10h10 Dr Vincenzo Martorana - Can SAXS experiments help in elucidating the structure of serpin protein polymers?
- 10h50 Coffee break
Closing Session
- 11h10 Pr David A. Lomas - Therapeutic strategies for antitrypsin deficiency
- 11h40 Closing remarks
PRACTICAL INFORMATIONS
REGISTRATION & Pricing
Registration has to be completed before the meeting and upon abstract acceptance by sending email to Maurine Villiers.
Registration fees include: conference participation, welcome cocktail on 27/09, light lunch on 28/09, coffee breaks.
| Private institutions | 250 EUR |
| Researchers | 180 EUR |
| Students | 60 EUR |
| Social dinner | 60 EUR |
Partners of the event
