September 24, 2020 - September 25, 2020

Novel host- and microbiota-directed strategies for treating respiratory infections


Respiratory infections ranked 4 in the WHO 2016 list of “Top 10 causes of death worldwide”. There is an urgent need for improved treatment of respiratory infections, in view of the absence of affordable treatment, but also because of the absence of effective drugs for selected respiratory pathogens and the increase in microbial resistance to conventional antibiotic treatment.

Recent insight into host defense mechanisms against respiratory infections and the respiratory microbiota have opened up new avenues for novel treatment strategies.

The aim of this Le Studium Conference is to bring together experts from a variety of European countries to discuss the latest developments in the field, and to explore future opportunities for collaboration with the Horizon 2020 program or related EU programs.

This international conference is organised in the framework of the BIOPHARMACEUTICALS ARD 2020 Programme.




Thursday 24th September 2020


  • 13:30    Welcome and introduction to the conference
    Sophie Gabillet (Le Studium Loire Valley Institute for Advanced Studies - France) and Dr Mustapha Si-Tahar (Research Center for Respiratory Pathologies [CEPR], Tours - France)

SESSION 1: New approaches to the treatment of respiratory infections

Chair: Mustapha Si-Tahar
  • 14:00    Prof. Pieter Hiemstra - Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects  
  • 14:30    Dr Nadia Naffakh - Antiviral potential of splicing regulatory molecules
  • 15:00    Coffee break

SESSION 2: Innovative experimental models to combat respiratory infections

Chair: Pieter Hiemstra
  • 15:30    Dr Anne van der Does - Lung-on-chip technologies to study respiratory infections 
  • 16:00    Dr Rodrigo Guabiraba - Precision cut lung slices: a novel versatile tool to examine host–pathogen interactions in the chicken lung  
  • 16:30    Dr Guido Santos - Multi-level computational modeling as a tool to understand molecular mechanisms behind bacterial lung infection 
  • 17:00    Closure of day 1

Friday 25th September 2020

SESSION 3 : Host metabolism as a druggable target for treatment of respiratory infections

Chair: Pieter Hiemstra
  • 13:30    Dr Aurélie Crabbé - Host metabolites modulate bacterial susceptibility to antibiotics  
  • 14:00    Dr Mustapha Si-Tahar - Towards a metabolic anti-influenza therapy 

SESSION 4 : Host and microbiota-derived inducers of host antimicrobial defence

Chair: Mustapha Si-Tahar
  • 14:30    Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy  
  • 15:00    Prof. Mike Surette - The Good and the Bad of Commensal-Pathogen Interactions in the Airways  
  • 15:30    Coffee break

SESSION 5 : HDT-based clinical trials and perspectives

Chair: Antoine Guillon
  • 16:00    Dr Antoine Guillon - Flagellin-based antibacterial strategy and clinical perspectives  
  • 16:30    Prof. Adrian Martineau - Vitamin D in the prevention and treatment of respiratory infections  
  • 17:00    Prof. Kingston Mills - Local T cells and their subversion in protective immunity to infection in the respiratory tract  


  • 17:30    Prof. Pieter Hiemstra - Conclusions

Click here to see the videos >


Booklet of abstracts3.05 MB

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