Medicinal flavor of metal complexes: diagnostic and therapeutic applications

December 07, 2015 - December 09, 2015

Hôtel Dupanloup
1, rue Dupanloup
45000 Orléans



FROM University of Debrecen, Faculty of Science and Technology, Department of Inorganic and Analytical Chemistry, Debrecen, Hungary

IN RESIDENCE AT Centre de Biophysique Moléculaire (CBM), UPR 4301 (Molecular Biophysics Center, CNRS) Orleans, France

  • Dr Eva JAKAB TOTHCentre de Biophysique Moléculaire (CBM), UPR 4301 (Molecular Biophysics Center, CNRS) Orleans, France


Metal ions play essential roles in biochemical processes, but they are also very important in diagnostic and therapeutic medicine. Because of toxicity (of metal-based diagnostic agents) or delivery issues (therapeutic agents based on bifunctional ligands) require specific ligands, which can encapsulate metal ions by forming stable and inert complexes. Diagnostic applications like MRI rely on the use of compounds containing paramagnetic ions (e.g., GdIII, MnII, FeII) while complexes with radionuclides emitting positrons (e.g., 44Sc, 64Cu, 68Ga, 86Y) or gamma photons (e.g., 99mTc, 111In) are employed in PET or SPECT, respectively. Luminescent lanthanide complexes emitting visible (EuIII and TbIII) or near-infrared light (e.g. NdIII, PrIII, ErIII and YbIII) have found utilization in various fields of optical imaging. Among the therapeutic applications the targeted radioimmunotherapy is being now more and more favored over the chemotherapy which rely on radionuclides that generate alpha (e.g. 212Pb, 212Bi) or beta (e.g. 90Y, 177Lu) particles but still require chelating ligands for delivery. The “LE STUDIUM® CONFERENCE” entitled “Medicinal flavor of metal complexes: diagnostic and therapeutic applications” intends to bring together leading scientists, from around the world, working on metal complexes with an aim to see and discuss how the achievements in one field can aid the research and development in the other filed.

Group picture


  • Prof. Dr. A. Dean SherryUniversity of Texas at Dallas and University of Texas Southwestern Medical Center, Richardson and Dallas, TX, USA
  • Prof. Dr. Peter CaravanHarvard Medical School and Massachusetts General Hospital, Charlestown, MO, USA
  • Prof. Dr. Carlos Platas-IglesiasUniversity of A Coruña, A Coruña, Spain
  • Prof. Dr. Imre TóthUniversity of Debrecen, Debrecen, Hungary
  • Dr. Róbert PálDepartment of Chemistry, Durham University, Durham, United Kingdom
  • Prof. Dr. Clotilde PolicarEcole Normale Supérieure (ENS), Laboratoire des BioMolécules, Paris, France
  • Dr. Célia S. BonnetCentre de Biophysique Moléculaire, CNRS, Orléans, France
  • Prof. Dr. Raphael TripierUniversité de Bretagne Occidentale, Brest, France
  • Prof. Dr. Sandrine (Markai) HuclierUniversity of Nantes, Nantes, France
  • Prof. Dr. Loïc CharbonniereCNRS Strasbourg, Strasbourg, France
  • Prof. Dr. Steven J. ArchibaldPositron Emission Tomography Research Centre and Department of Chemistry, University of Hull, Hull, United Kingdom
  • Prof. Dr. Carlos Frederico de Gusmão Campos GeraldesUniversity of Coimbra, Coimbra, Portugal
  • Prof. Dr. Philip BlowerDepartment of Imaging Chemistry and Biology, King's College London, London, United Kingdom
  • Dr. Svetlana V. EliseevaCentre de Biophysique Moléculaire, CNRS, Orléans, France
  • Dr. Goran AngelovskiMax Plank Institute for Biological Cybernetics, Tübingen, Germany


1st Day - 07/12/15

12:00    Registration/Welcome Lunch

13:30    Official opening    

  • President of LE STUDIUM Ary Bruand;
  • Scientific director of LE STUDIUM, Prof. Nicola Fazzalari     

13:40    Sponsorship acknowledgement with a special thank to the University of Debrecen    

LE STUDIUM fellow, Dr. Gyula Tircso    

13:50    Scientific opening    

CBM Director Dr. Eva Jakab Toth    

First session     Chairman: Dr. Éva Jakab Tóth    

14:00    1st presentation    

Functional imaging of Zn(II) relelase from secretory cells by MRI    Prof. A. Dean Sherry

14:45    2nd presentation    

Scandium : is it the new generation of fashion theranostic agent?    Dr. Sandrine (Markai) Huclier

15:15    Oral communication 1    

Translating the activity of an enzyme analyte into beating the chelate effect    Prof. Jens Hasserodt

15:35    Coffee break and Poster Section        

Second session     Chairman:  Prof. Stéphane Petoud    

16:35    3rd presentation    

Designing and studying efficient azamacrocyclic chelators for nuclear medicine applications    Prof. Raphael Tripier

17:05    4th presentation    

Luminescent Lanthanide(III)-based Metallacrowns as Promising Agents for Optical Imaging Applications    Dr. Svetlana Eliseeva

17:35    Oral communication 2    

Near-Infrared Imaging of Necrotic Cells Using LnZn16 Metallacrowns    Ivana Martinic


Les métaux et la vie    Prof. Clotilde Policar

2nd Day - 08/12/15

08:45    Registration/Welcome Coffee        

Third session    Chairman: Prof. A. Dean Sherry    

09:00    5th presentation    

Molecular MR Imaging    Prof. Peter Caravan

09:45    Oral communication 3    

Stability of Cu(II) Chelates based on thiazolyle-cyclam derivatives for PET Imaging    Dr. Véronique Patinec

10:05    6th presentation    

In the Pursuit of Higher Resolution in Optical Microscopy: From Lanthanides to Super-Resolution    Dr. Róbert Pál

10:35    Coffee break        

Fourth session     Chairman: Prof. Lothar Helm    

11:05    7th presentation    

Responsive MRI contrast agents    Dr. Célia S. Bonnet

11.35    Oral communication 4    

A nanogel approach to tune conventional MRI Contrast Agents into hypersensitive MRI probes: application to Lymph Node Molecular Imaging (LNMRI)    Dr. Cyril Cadiou

11:55    Oral communication 5    

"Exploring the potentialities of two-photon lanthanide luminescent bioprobes"    Anh Thy Bui

12:15    Lunch        

Fifth session     Chairman: Prof. Peter Caravan    

14:00    8th presentation    

Nuclear Chocolate Box – the Periodic Table of Nuclear Medicine    Prof. Philip Blower

14:45    9th presentation    

Chemokine receptor targeted radiopharmaceuticals and radiolabelled nanoparticles for positron emission tomography imaging    Prof. Steven J. Archibald

15:15    10th presentation    

Bioresponsive Nano-sized Contrast Agents for Functional MRI    Dr. Goran Angelovski

15:45    Coffee break and Poster session 

Sixth session    Chairman: Prof. Kristina Djanasvili    

16:45    11th presentation    

Inorganic Cellular Chemistry: Anti-Superoxide Complexes Evaluated in Cells and Metal-Carbonyl Derivatives for IR-imaging    Prof. Clotilde Policar

17:15    Oral communication 6  

 Synthesis and preclinical evaluation of a 64Cu-labeled ligand of the prostate specific membrane antigen (PSMA): A promising radiopharmaceutical for prostate cancer imaging.  Dr. Victor Goncalves

17:35    Oral communication 7    

A premier on structural tricks applied to accelerate formation kinetics of radiometal - macrocyclic ligand complexes    Dr. Gyula Tircsó

17:55    Oral communication 8    

Solution coordination chemistry as a first step in qualifying new chelators designed for nuclear medical applications    Dr. Michel Meyer

20:00    Conference gala dinner 

3rd Day - 09/12/15

08:45    Morning coffee        

Seventh session    Chairman: Prof. Petr Hermann    

09:00    12th presentation    

Formation kinetics of M(III)DOTA complexes: similarities and differences in aqueous solutions and water –ethanol mixtures    Prof. Imre Tóth

09:30    13th presentation    

Some Mn(II)/Mn(III) complexes as alternative potential MRI contrast agents    Prof. Carlos F.G.C. Geraldes

10:00    Oral communication 9    

"Gd(III) complexes appended to porphyrin sensitizers: water-soluble theranostic agents for MRI and one/two-photon PDT"    Dr. Angélique Sour

10:20    Coffee break        

Eigths session     Chairman: Prof. Imre Tóth    

10:50    14th presentation    

From molecules to nanoparticles: exchanging rules in lanthanide based luminescent compounds    Dr. Loïc Charbonniere

11:20    15th presentation    

Exceptionally inert lanthanide(III) PARACEST MRI contrast agents based on 18-membered macrocyclic platforms    Prof. Carlos Platas-Iglesisas

11:50    Oral communication 10  

Smart theranostics: a useful tool for tracking metal-based complexes    Dr. Ewen Bodio

12:10    Oral communication 11    

Lanthanide Containing Liponanoparticles in Theranostic Approaches    Dr. Éva Jakab Tóth

12:30    Conclusions & closing ceremony    

               Scientific conclusions: Prof. Nicola Fazzalari and  Dr. Éva Jakab Tóth

               Closing speech: Dr. Éva Jakab Tóth and Dr. Gyula Tircsó    

12:40    Lunch - sandwich bar & take away        


  • Chemistry of Contrast Agents (CA’s) in Magnetic Resonance Imaging (MRI) and its implications to the ligand design in other fields: (state of the art, Gd3+ and non-Gd3+-based CA’s, smart imaging agents, imaging at molecular level, etc.).
  • Trends in nuclear medicine (diagnostic and therapeutic isotopes and applications, ligands design, new radiolabeling strategies, etc.).
  • Ln3+ complexes for diagnostic applications in optical imaging (luminescent Ln3+ complexes, lanthanide(III)-ion based biosensors, etc.).



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