Characterization of limbic system connectivity through fiber dissection and diffusion imaging techniques

LE STUDIUM Multidisciplinary Journal, 2019, 3, 64-88

Igor Lima Maldonado1,5, Christophe Destrieux1, 3, 6


1UMR Inserm U1253, iBrain, Université de Tours, Tours, France

2Le Studium Loire Valley Institute for Advanced Studies, Orleans, France

3CHRU de Tours, Tours, France

4Departamento de Biomorfologia - Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brasil

5Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador, Brasil

6Laboratory of Anatomy - Faculté de Médecine - 10 bd Tonnellé - 37032 Tours – France


Although cortical elements of the limbic system are quite well defined, the underlying white matter pathways are not well detailed. This project aimed to better describe white matter tracts of the limbic system using both fiber dissection, and in and ex vivo Diffusion Weighted Imaging (DWI) techniques. In vivo data (from DWI and neuropsychological evaluations) were obtained from healthy subjects aged 82 and over previously enrolled in the FIBRATLAS project funded by the French Research Agency and run in the host laboratory. Correlations between neuropsychological and white matter characteristics on DWI were examined in this group to infer function of the limbic white matter tracts. Ex vivo data from the FIBRATLAS project database and from the Tours Body Donation Program were examined. The brains were extracted and used to study the anatomy of the limbic white matter tracts employing both DWI and fiber dissection according to a variant of the Klingler’s method.


Limbic lobe
Cingulate gyrus
White matter
Diffusion imaging
Magnetic resonance
Fiber dissection
Published by

Le STUDIUM Multidisciplinary Journal