RNA therapeutics and Neuroscience
Virtual meeting: instructions to connect are communicated upon registration.
The RNA & NEUROSCIENCE meeting aims to bring together graduate students, academic and industry scientists working in the fields of RNA and the Central Nervous System (CNS) to present their latest research results, ideas, developments, biological medical applications and discuss the current concepts and the challenges that we are facing for future research.
RNA therapeutics is a novel technology that provides a unique treatment for a variety of diseases. While it has been a success for the COVID19 pandemic, the RNA community still has the challenge on delivering some of these RNA molecules in other parts of the body (e.g. brain and cardiac tissue) and better specificity to have a full therapeutic effect. Therefore, this meeting will explore the novel RNA therapeutics that are been currently developing and their mechanisms to cure a variety of diseases.
Additionally, the complexity of the brain provides a unique challenge to find therapeutics to cure neurodevelopmental disorders and neurodegenerative diseases such as Alzheimer’s and ALS. These diseases are characterized by the lack of gene regulation causing protein imbalance at the synapses and therefore cell death. Thus, in this meeting we will also explore the mechanisms that cause these diseases and the novel therapeutics that are currently being developed for their cure.
This international conference is organised in the framework of the BIOPHARMACEUTICALS ARD CVL Programme.
RNA therapeutics, RNA molecules, Neurosciences, Neurodevelopment diseases, Neurodegenerative diseases, Central Nervous System (CNS), RNA therapy, RNA delivery and Gene regulation
- Dr Kathia Zaleta, LE STUDIUM / Marie Skłodowska-Curie Research Fellow
FROM: University of California San Diego (UCSD) - USA
IN RESIDENCE AT: Imaging and Brain Unit (iBrain), INSERM / University of Tours - FR
- Prof. Patrick Vourc'h
Imaging and Brain laboratory Unit (iBrain), INSERM / University of Tours - FR
- Dr Minerva Hernández Lozano, Faculty of Biological Pharmaceutical Chemistry, University of Veracruz - MX
- Dr Frédéric Laumonnier, Imaging and Brain Unit (iBrain), INSERM / University of Tours – FR
- Dr Fédérico Perche, Center for Molecular Biophysics (CBM) / CNRS – FR
- Prof. Chantal Pichon, Center for Molecular Biophysics (CBM) / CNRS – FR
- Prof. Patrick Vourc'h, Imaging and Brain Unit (iBrain), INSERM / University of Tours - FR
- Dr Kathia Zaleta, University of California San Diego – USA
- Dr Horacio Cabral, School of Engineering , The University of Tokyo - JP
- Dr Ana Cristina Calvo, Department of Animal Anatomy, Embryology and Genetics, University of Zaragoza - ES
- Prof. Steven Dowdy, University of California San Diego (UCSD) - USA
- Prof. Stefano Gustincich, Italian Institute of Technology (IIT) - IT
- Prof. Michelle L. Hastings, Rosalind Franklin University of Medicine & Science - USA
- Dr Lori L. Isom, University of Michigan Medical School - USA
- Dr Débora Lanznaster (Imaging and Brain laboratory (iBrain), INSERM / University of Tours - FR) - Combined Metabolomics and targeted-transcriptomics analysis in the muscle of early-stage ALS patients
- Dr Jean-René Martin,The Paris-Saclay Institute of Neuroscience (NeuroPSI) / CNRS, University Paris-Saclay - FR
- Dr Liliane Massade, Diseases and Hormones of the Nervous System (DHNS), INSERM /CNRS / University of Paris-Saclay & Paris Sud – FR
- Director Jason Potter, Director of Cell Biology R&D from ThermoFisher Scientific - USA
- Prof. Antonella Riccio, University College London (UCL) - UK
- Prof. Krzystof Sobczak, Adam Mickiewicz University - PL
- Prof. Jernej Ule, Francis Crick Institute - UK
Tuesday 24th May (14:00-18:50 Gmt+2 Paris)
14:00 Official Opening by Sophie Gabillet, Dr Kathia Zaleta & Prof. Patrick Vourc'h
Session 1 : RNA REGULATION
Chairman: Dr Frédéric Laumonnier
- 14:30 Prof. Antonella Riccio - RNA metabolism in developing neurons
- 15:10 Dr Ana Cristina Calvo - Peripheral RNA Biomarkers in Amyotrophic Lateral Sclerosis
- 15:50 Dr Débora Lanznaster - Combined Metabolomics and targeted-transcriptomics analysis in the muscle of early-stage ALS patients
- 16:30 Coffee break
Session 2: RNA DELIVERY
Chairman: Prof Chantal Pichon & Dr Fédérico Perche
- 16:50 Dr Horacio Cabral - RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery
- 17:30 Prof. Steven Dowdy - Delivery of RNA Therapeutics: The Great Endosomal Escape!
- 18:10 Director Jason Potter - What matters for making highly expressed mRNA.
- 18:50 End of the conference day
Wednesday 25th May (14:00-19:00 Gmt+2 Paris)
Session 3: RNA THERAPEUTICS - Part 1
Chairman: Prof. Patrick Vourc'h
- 14:00 Prof. Jernej Ule - How do protein-RNA condensates form and contribute to disease?
- 14:40 Dr Liliane Massade - Squalenoyl siRNA PMP22 nanoparticles, a potent therapy for Charcot-Marie-Tooth disease type 1A
- 15:20 Dr Jean-René Martin - The snoRNA jouvence, a new versatile tool to protect against the deleterious effects of ageing, as well as inversely, for the treatment of cancer.
- 16:00 Prof. Krzystof Sobczak - Compounds which alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats in the Fragile X–associated syndrome
- 16:40 Coffe break
Session 4: RNA THERAPEUTICS - Part 2
Chairman: Dr Kathia Zaleta
- 17:00 Prof. Stefano Gustincich - Antisense long non-coding SINEUP RNAs: from molecular mechanism to therapeutics
- 17:40 Prof. Michelle L. Hastings - Antisense Oligonucleotides for the Treatment of Disease
- 18:20 Dr Lori L. Isom - Dancing to a different tune: TANGO offers a precision medicine approach to treating Dravet syndrome
- 19:00 Conclusion
- Fatima Khatoon (Amity Institute of Neuropsychology and Neurosciences - IN) - Network Based Approach for Targeting Human Kinases commonly associated with ALS and Other diseases
- Kartikay Prasad (Amity Institute of Neuropsychology and Neurosciences - IN) - Extensive network-based approach to identify the potential biomarkers of Amyotrophic Lateral Sclerosis
- Ana Šarić (Center for Molecular Biophysics (CBM) / CNRS - FR) -