LE STUDIUM Guest Research Fellow
In residence at
Dr Lucie Pellissier
Understanding cellular and molecular basis of autism spectrum disorders
I am interested in understanding the presynaptic protein’s contribution/synaptic signaling towards the brain functions in healthy and diseased states. My previous work at Leibniz institute for Neurobiology (LIN) and Institute of Biology at Otto-von-Guericke University, Magdeburg in Germany dealt with one of the important presynaptic protein “Bassoon” and its role in hippocampus and interneuron-dependent functions and dysfunctions towards cognition, learning and memory in mice.
During my postdoctoral research at Dr. Lucie Pellissier’s research group at INRAE, Nouzilly, I will be part of the ERC (European Research Council) funded research project headed by Dr. Pellissier. The main theme of the research work is to “study cellular and molecular basis of autism spectrum disorders”. Autism spectrum disorders are brain pathological conditions, occurs in children and are having social and economic burden. There is no certain known mechanism behind the disease progression and no appropriate treatment strategies either to treat the children with these devastating conditions. During the tenure, I will analyze the brain tissues from different mouse models of autism spectrum disorder having social deficits behavior, using RNA seq/single cell transcriptomics approaches in order to identify novel cellular and molecular substrates. These targets will be further validated in different anatomical regions of brain across the species using immunohistochemical approaches.
Annamneedi A#, del Angel M, Gundelfinger ED, Stork O, Caliskan G#. (2021) The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling. International Journal of Molecular Sciences 22(15):7944. doi: 10.3390/ijms22157944. # shared correspondence.
Montenegro-Venegas C*, Annamneedi A*, Hoffmann-Conaway S, Gundelfinger ED, Garner CC. (2020) BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy. Autophagy. Epub ahead of print. doi: 10.1080/15548627.2020.1801259. * equal contribution.
Annamneedi A*, Caliskan G*, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger E.D, Stork O. Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance. Brain Struct Funct. 2018 Jun 18; 223:3423–3445. doi: 10.1007/s00429-018-1692-3. * equal contribution.