Synthesis and Isolation of Bio-Active Molecules (SIMBA)

The research themes developed within our team focus on the development of bioactive molecules for oncology and infectiology. A first fundamental axis focuses on the development of new access routes to these molecules by synthesis or isolation from natural resources. The second applied axis focuses on the biological evaluation of molecules synthesized or isolated in the laboratory (anti-cancer, anthelmintic, antifungal, antibacterial).

Research topics:

• Development of new methodological tools for the syn­thesis and functionalization of heterocycle scaffolds
• Synthesis and isolation of anti-infectious and an­ti-cancer molecules
• Innovation in Extractive Chemistry: Centrifugal Parti­tion Chromatography, Deep Eutectic Solvents.

Equipment and technology:

• X-ray diffraction (XRD)
• DAD HPLC chains, HPTLC-densitometry, GC-FID
• PLC-MS chain
• RX Fluorescence
• Centrifugal Partition Chromatography (CPC)
• Synthesis microwave
• Microplate reader
• Combiflash purification system
• TRA IR spectrometer