Niche, Nutrition, Cancer & Oxidative metabolism (N2COX)

Our research project is a project of a multidisciplinary single team focused on lipids, acting on metabolism and calcium signalling, able to delay tumor progression and to increase the sensitivity of tumors to anti-cancer drugs.

The laboratory’s work has 3 long-term objectives:

• To define favorable conditions for primary cancer prevention by diet
• To improve cancer treatments
• To reinforce the physiology of the patient by preventing cancer-related cachexia.

Research topics:

• Oncology: lipids and prevention
• Chemosensitization of tumors to anticancer treatments
• Signal transduction and biology of cancer cells
• Clinical nutrition: energy metabolism, cachexia, mitochondrial bioenergetics
• Role and mechanism of action of ion channels, calcium homeostasis

Equipment and technology:

• Microspectrofluorimetry / imaging and fluorescent probes
• Oxygraph
• Indirect calorimetry
• Electrophysiology platform
• Techniques of RT-qPCR, plasmid transfections
• HPLC in gaseous phase, HPTLC
• Fluorescence microscopes and macroscope
• Time lapse
• Histopathology platform
• Measurement of natural isotopic abundances by EA-IRMS
• Body composition by multi-frequency impedance and biphotonic absorptiometry