September 24, 2020 - September 25, 2020

Novel host- and microbiota-directed strategies for treating respiratory infections

Change of dates! Due to the COVID-19 crisis, the conference has been postponed to 24th & 25th September 2020

Respiratory infections ranked 4 in the WHO 2016 list of “Top 10 causes of death worldwide”. There is an urgent need for improved treatment of respiratory infections, in view of the absence of affordable treatment, but also because of the absence of effective drugs for selected respiratory pathogens and the increase in microbial resistance to conventional antibiotic treatment.

Recent insight into host defense mechanisms against respiratory infections and the respiratory microbiota have opened up new avenues for novel treatment strategies.

The aim of this Le Studium Conference is to bring together experts from a variety of European countries to discuss the latest developments in the field, and to explore future opportunities for collaboration with the Horizon 2020 program or related EU programs.

This international conference is organised in the framework of the BIOPHARMACEUTICALS ARD 2020 Programme.




Thursday September 24th 2020

  • 15:00    Registration and welcome coffee
  • 15:45    Official opening : Sophie Gabillet  (LE STUDIUM Loire Valley Institute for Advanced Studies) and Dr Mustapha Si-Tahar (Research Center for Respiratory Diseases (CEPR))

SESSION 1: Host and microbiota-derived inducers of host antimicrobial defence

  • 16:15    Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy
  • 16:45    Prof. Mike Surette - Pathogens, commensals and polymicrobial interactions in respiratory infections
  • 17:15    Dr Philippe Langella - Genetically-modified probiotics in human health
  • 18:15    Guided visit of the historical center of Tours
  • 19:30    Social dinner (upon registration)

Friday September 25th 2020

SESSION 2: Host metabolism as a druggable target for treatment of respiratory infections

  • 08:30    Welcome coffee
  • 08:45    Dr Markus Maeurer - Immunometabolism and pulmonary infections: Implications for protective immune responses and host-directed therapies
  • 09:15    Dr Aurélie Crabbé  - Host metabolites enhance the activity of antibiotics
  • 09:45    Dr Mustapha Si-Tahar - Towards a metabolic anti-influenza therapy
  • 10:15    Coffee break

SESSION 3: Non-metabolic host therapies against respiratory infections

  • 10:45    Prof. Pieter Hiemstra - Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects.
  • 11:15    Prof. Viktor Volchkov - Role of lectins in the lung manifestations of Ebola virus infection
  • 11:45    Dr Nadia Naffakh - Splicing complex destabilizing molecules as an antiviral therapy
  • 12:15    Lunch

SESSION 4: Innovative experimental models to decipher respiratory infections

  • 13:30    Dr Guido Santos - Multi-level computational modeling as a tool to understand molecular mechanisms behind bacterial lung infection
  • 14:00    Dr Anne van der Does - Lung-on-chip technologies to study respiratory infections
  • 14:30    Dr Rodrigo Guabiraba - Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in lungs
  • 15:00    Coffee break

SESSION 5: Clinical trials and perspectives of Host-directed therapies

  • 15:20    Prof. Adrian Martineau - Vitamin D in the treatment of respiratory infections
  • 15:50    Prof. Kingston Mills - Immune checkpoint inhibition in the treatment of chronic infections
  • 16:20    Dr Antoine Guillon - Flagellin-based antibacterial strategy and clinical perspectives
  • 16:50    Conclusions: Prof. Pieter S. Hiemstra


(Including a lunch and the coffee breaks)

Private institutions 150 EUR
Public institutions 100 EUR
Students & PhD Scholars 50 EUR
Social dinner 60 EUR

Partners of the event