Being Smart In Coordination Chemistry: Medical Applications

Deadline for registration: 22/09/2016

Metal complexes have increasing importance in modern medicine. Early recognition of diseases, which is the cornerstone of successful therapies, is one of the most important goals in medical imaging. To meet this challenge, one needs to explore and to visualize the alterations in the molecular events of biological processes, from the homeostasis of a simple metal ion to the complex functioning of biomolecular assemblies. For this, even the most sophisticated instrumentational tools like MRI, PET, SPECT or optical imaging need to be complemented with the appropriate chemistry. Many of the diagnostic agents, indispensable in molecular imaging approaches, are based on metal complexes.

Among the numerous therapeutic applications that rely on metal ions, one emerging field is radioimmunotherapy. It uses radionuclide-labelled antibodies to deliver radiation exclusively to cancerous cells minimalizing side effects.

In order to circumvent toxicity and to ensure specific delivery, metal ions are trapped into various scaffolds, ranging from small chelators to specifically-designed multifunctional nanoparticles. They all have to fulfill strict requirements of tight binding in order to carry the metal ion safely to the target.

The “LE STUDIUM CONFERENCE” entitled “Being smart in coordination chemistry: medical applications” intends to bring together different actors of the research and medical application of metal complexes, including chemists, biochemists and physicians in the objective of confronting different views, exploring medical needs and potential responses.

TOPICS

• New approaches in Magnetic Resonance Imaging.
• Metal ions in nanostructures for improved medical diagnosis.
• Complexes of metal ions in medical therapy.
• Responsive probes for real-time monitoring of physicochemical parameters and for determining the concentration of biologically relevant ions and molecules.

Convenors

• Dr Ferenc Kàlmàn, LE STUDIUM RESEARCH FELLOW
  FROM Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, Hungary
  IN RESIDENCE AT Centre de Biophysique Moléculaire (CBM), UPR 4301 (Molecular Biophysics Center, CNRS) Orleans, France
• Dr Éva Jakab Tóth
  Centre de Biophysique Moléculaire (CBM), UPR 4301 (Molecular Biophysics Center, CNRS) Orleans, France

Invited Speakers

• Dr Kristina Djanashvili - Biocatalysis and Organic Chemistry, Department of Biotechnology, Delft University of Technology (NL)
• Dr Simonetta Geninatti - Chemistry and Preclinical Research Team (CPRT), Molecular Imaging Center (IT)
• Dr Gyula Tircsó - Department of Inorganic and Analytical Chemistry, University of Debrecen (HU)
• Prof. Ervin Berényi - Department of Biomedical Laboratory and Imaging Science, Faculty of Medicine, University of Debrecen (HU)
• Dr László Sasi Szabó - Department of Pediatric Surgery, Institute of Pediatrics, University of Debrecen (HU)
• Dr Ildikó Garai - ScanoMed (HU)
• Dr Zoltán Kovács - The University of Texas Southwestern Medical Center (USA)
• Dr Alessandro Maiocchi - Bracco Imaging SpA (IT)
• Dr Gábor Papp - Department of Physical Chemistry, University of Debrecen (HU)
• Pr Franck Denat - Institute of Molecular Chemistry of the University of Burgundy (FR)
• Pr Silvio Aime - Chemistry and Preclinical Research Team (CPRT), Molecular Imaging Center (IT)
• Pr Olivier Tillement - Institut Lumière Matière, Université Claude Bernard Lyon (FR)
• Dr Alain Le Pape - Centre d’Imagerie du Petit animal, CIPA-TAAM, UPS n°44, CNRS, Orléans (FR)
• Dr Sara Lacerda - CBM, CNRS, Orléans (FR)
• Dr Graeme Stasiuk - University of Hull (UK)
• Dr Pascale Delangle - Reconnaissance Ionique et Chimie de Coordination, Laboratoire de Chimie Inorganique et Biologique(UMR E 3 CEA UJF) (FR)

PROGRAMME / SCHEDULE

1st DAY 26/09/2016 

• 12H00 Registration/Welcome lunch
• 13H30 Official opening
• 13H40 Acknowledgement (Dr Ferenc Kàlmàn)
• 13H50 Scientific opening (Dr Éva Jakab Tóth)

First session

• 14H00    Pr Silvio Aime
  Design and testing of paramagnetic agents for functional and molecular MRI studies
• 14H40    Pr Franck Denat
  Macrocyclic polyamines as multifunctional chelating agents for medical imaging
• 15H10    Dr Gábor Papp
  Application of para-H2 in hydrogenation reactions catalyzed by Ru-, Rh- and Ir-complexes in aqueous media
  15H30    Coffee break and poster section

Second session

• 16H30    Pr Olivier Tillement 
  Use of gadolinium-based hybrid nanoparticles for enhanced radiation therapy guided by MRI
• 17H00    Dr Kristina Djanashvili
  Advantages of Porous Nanomaterials for Theranostic Applications 
• 17H30     Zoltán Garda
  Toward Safe Magnetic Resonance Imaging Contrast Agent: Mn(II) Complexes Of Open-Chain Bis(Amide) Derivatives
• 18H30    Pr Franck Denat
  Chimie & Métaux: du diagnostic médical aux thérapies
  French grand public conference, LE STUDIUM LECTURE

2nd DAY 27/09/2016

• 08H45  Registration/Welcome coffee

Third session

• 09H00    Pr Ervin Berényi 
  Multimodal Imaging. New approaches in Magnetic Resonance Imaging
• 09H40    Dr Alain Le Pape 
  PET and SPECT in the arena of preclinical imaging strategies to boost therapy innovation in cancer research
• 10H10    Morgane Enel 
  PCTA scaffold-based LnIII complexes : synthesis and evaluation
• 10H30    Coffee break

Fourth session

• 11H00    Dr Ildiko Garai
  From Biomarkers to Teranostics: The future perspectives in medical therapy using radiolabelled molecules
• 11H40    Dr László Sasi Szabó 
  Intraoperative tissue identification – the surgeon’s point of view
• 12H10    Pr Géraldine Gouhier 
  β-Cyclodextrins as scaffolds of new smart MRI contrast agents
• 12H30    Lunch

Fifth session

• 14H00    Dr Alessandro Maiocchi
  About the role of metal complexes in the future of medical imaging applications
• 14H40    Dr Sara Lacerda
  Peptide-based Contrast Agents: Novel probes for high-risk atherosclerotic plaques and metastasis imaging
• 15H10    Dr Pascale Delangle
  Metal-coordinating peptides as tools to understand copper homeostasis and treat Wilson Disease
• 15H40    Coffee break and Poster session

Sixth session

• 16H30    Dr Zoltan Kovacs 
  A Eu(II) / (III) based redox responsive T1 / PARACEST agent
• 17H10    Dounia El Hamrani 
  Perinatal exposure to dichloro-bisphenol A alters hepatic lipid composition in mouse: a study by MRI and 1H MRS
• 17H30    Dr Éva Jakab Tóth
  Enzyme-responsive imaging probes based on a self-immolative approach
• 20H00    Conference gala dinner at Le Lift

3rd DAY 28/09/2016

• 08H45 Morning coffee

Seventh session

• 09H00    Dr Simonetta Geninatti Crich 
  Proteins as carriers for metal based theranostics
• 09H30    Dr Graeme J. Stasiuk 
  Molecular imaging agents for the detection of Formyl Peptide Receptor 1 in inflammation
• 10H00    Dr Gyula Tircsó 
  Improving the Safety of Magnetic Resonance Imaging Contrast Agents: Preparation and Characterization of New Gd3+ and Mn2+ Complexes Formed with Rigidified Ligands.
• 10H20    Coffee break

Eighth session

• 10H50    Dr Ferenc K. Kálmán
  Results of a detailed investigation on a Mn(II)-based “smart” MRI contrast agent candidate for angiographic investigation
• 11H10    Dr Matthieu Starck
  Europium complexes for cell imaging
• 11H30    Raphaël Gillet 
  New bispidine based ligand as stable copper chelate for nuclear imaging application
• 11H50    Conclusions & closing ceremony
  Scientific conclusions: Dr Éva Jakab Tóth
  Closing speech: Dr Éva Jakab Tóth & 
  Dr Ferenc Kàlmàn
• 12H00    Lunch

Pricing

ABSTRACTS & POSTER SUBMISSION

Abstracts, Bio & Posters must be written in English and be sent before the 12/09/2016

Please send your poster before the 15/09/2016 so that it can be included on the USB flash drive. Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes