September 27, 2017 - September 29, 2017

The role of glycosylation on serpin biology and conformational disease

The aim of the conference is to bring together scientists working on the molecular aspects of protein conformational disease, specifically on serpinopathies, and on the role of glycosylation on the folding, stability, function and cellular fate of serpin proteins. Although this topic is recognised as an important aspect in the field, it has not been the focus of a dedicated conference so far. This event aims to be a milestone in the broader topic of the role of glycosylation on conformational disease, devoting a substantial time to open discussion with the intention of fostering collaborations and promoting new ideas.

  Immunoshape Session

Glycoscience, which focuses on the study of the structural and functional roles of carbohydrates in their biological context, has an increasing impact on many areas such as biotechnology, health, food and energy. IMMUNOSHAPE is a Marie Curie European Training Network that provides multidisciplinary and multisectorial training in biomedical glycoscience and its industrial applications to a new generation of young scientists. The training  course on  Intellectual property strategy and applications in life sciences will be on the morning of September 27th and is open to all the participants of the LE STUDIUM Conference on The role of glycosylation on serpin biology and conformational disease.

Please specify your interest in attending this training session in your registration form. Registration to the session is free but mandatory.

LOCATION

CONVENORS

  • Dr Mauro Manno, LE STUDIUM / Marie Skłodowska-Curie Research Fellow.
    FROM: CNR Institute of Biophysics, Palermo, IT
    IN RESIDENCE AT:
    Institute of Organic and Analytical Chemistry (ICOA) - University of Orléans/CNRS - Orléans - FR
  • Pr Richard Daniellou
    Institute of Organic and Analytical Chemistry (ICOA) - University of Orléans/CNRS - Orléans - FR 

SPEAKERS

SCIENTIFIC COMMITTEE

  • Pr Richard Daniellou, University  of Orléans - FR
  • Dr Mauro Manno, CNR Institute of Biophysics at Palermo - IT
  • Dr Maria Elena Miranda Banos, Sapienza Univ. of Rome - IT

MAIN TOPICS

Glycosylation, serpins, serpinopathies, protein conformational disease, protein folding and misfolding, protein traffickig

CALL FOR ABSTRACT

Abstracts, Bio & Posters must be written in English. 

Abstract are requested for oral and poster presentations focused on specific topic area including glycosylation, serpins, serpinopathies, protein conformational disease, protein folding and misfolding, protein trafficking.

Abstract are limited to 250 words, and should be submitted via email to Maurine Villiers

Due date Friday 18th August 2017 for oral presentations & posters.

Conference PROGRAM

Wednesday September 27th 2017

Immunoshape session

IP IN PHARMACEUTICAL AND DIAGNOSTIC PRODUCT DEVELOPMENT
  • 09h00   IP Lecture by William Hammond (French Patent Attorney)
  • 10h30   Coffee break
  • 10h45   IP Case studies by William Hammond (French Patent Attorney)
  • 12:30    Welcome lunch & registration

Opening session

  • 14:00   Opening
  • 14:30   H2020 funding opportunities, Thomas Rochette-Castel (Cellule Mutualisée Europe Recherche - CMER)
  • 15:00   Pr Marco Cicardi - SERPING1 mutations, a serpinopathy leading to recurrent angioedema
  • 15:30   Coffee break

Session 1: Glycosylation and its clinical implication in Serpinopathies

  • 16:00   Pr Philippe Delannoy - Protein glycosylation: nature, biosynthesis and disease implications
  • 16:30   Pr Javier Corral - Glycosylation of antithrombin: data from patient
  • 17:00   Pr Markus Glatzel - Insights into the pathophysiology of Familial Encephalopathy with Neuroserpin Inclusion Bodies using murine models
  • 17:45   Orléans city center guided visit
  • 19:15   Wine & cheese cocktail at Hôtel Dupanloup

Thursday September 28th 2017

Session 2: Neuroserpin: function, dysfunction, therapy

  • 08:30   Welcome coffee
  • 09:00   Pr Denis Vivien - Single chain tPA versus two chain tPA from fibrinolysis to neuronal signaling
  • 09:30   Pr Giovanna Galliciotti - Neuroserpin in nervous system development, manteinance and degeneration
  • 10:00   Pr Stefano Ricagno - Effects of embelin in neuroserpin polymerisation
  • 10:30   Coffee break & posters session

Session 3: ER: Stress, accumulation, clearance

  • 10:50   Pr Stefan Marciniak - Measuring ER viscosity: relevance to alpha-1 antitrypsin deficiency
  • 11:20   Dr Benoit Roussel - Non-proteolytic roles for the serine protease tPA in the ischemic brain: interactions and modifications on the ER stress and autophagic pathways
  • 11:50   Ilaria Fregno - Clearance of proteosome-resistant protein polymers from the mammalian ER
  • 12:10   Dr Riccardo Ronzoni - Kinetics of Z α1-antitrypsin polymers: intracellular accumulation and secretion
  •  12:30   Lunch

Session  4: Glycosylation and its biological implication in Serpinopathies

  • 14:00   Dr Maria Elena Miranda Banos - Neuroserpin polymers from the cell biology perspective: effects of N-glycosylation and induction of oxidative stress in cell models of dementia FENIB
  • 14:30   Pr Bibek Gooptu - Biophysical characterisation of glycosylation and its effects in α1-antitrypsin
  • 15:00   Dr Irene Martínez Martínez - Study of the antithrombin folding using the N-glycosylation as a tool
  • 15:30   Dr María Eugenia de la Morena-Barrio - Defects of N-glycosylation on antithrombin
  • 15:50   Coffee break

Session  5: Post-translational heterogeneity 

  • 16:10   Dr Sonia Caccia - C1-Inhibitor, The Heavy Serpin
  • 16:40   Pr Anna Fra - Uncommon behaviour of rare Alpha-1 Antitrypsin variants
  • 17:10   Mattia Laffranchi - Hetero-polymerization of Z AAT with other alpha1-antitrypsin variants in cellular models
  • 17:30   Jihen Ati - Glycosylate me, LEXSY !
  • 17:50   Open session and discussion on Networking
  • 20:15   Social Dinner

Friday September 29th 2017

Session  6: Polymers: pathways, structures

  • 08:30   Welcome coffee
  • 09:10   Dr Mauro Manno - The well-tempered polymerisation of neuroserpin: a biophysical perspective
  • 09:40   Dr James Irving - Tools for probing the alpha-1-antitrypsin polymerisation pathway
  • 10:10   Dr Vincenzo Martorana  - Can SAXS experiments help in elucidating the structure of serpin protein polymers?
  • 10:50   Coffee break

Closing Session

  • 11:10   Pr David A. Lomas - Therapeutic strategies for antitrypsin deficiency 
  • 11:40   Closing remarks

 

PRACTICAL INFORMATIONS

REGISTRATION & Pricing

Registration has to be completed before the meeting and upon abstract acceptance by sending email to Maurine Villiers.

Registration fees include: conference participation, welcome cocktail on 27/09, light lunch on 28/09, coffee breaks.

Private institutions 250 EUR
Researchers 180 EUR
Students 60 EUR
Social dinner 60 EUR

Partners of the event