March 22, 2017 - March 23, 2017

Messenger RNA therapeutics: advances and perspectives

Messenger RNA therapeutics: advances and perspectives

Deadline for registration: 15/03/2017

In the framework of the regional Biopharmaceuticals ARD2020 Programme, LE STUDIUM Loire Valley Institute for Advanced Studies together with the Center for Molecular Biophysics are organising an international conference on mRNA therapeutics advances and perspectives.
The continuous research over a decade has led to excellent progress in the mRNA biology field and has extended our understanding of the distinctive features of mRNA. At this stage, researchers have learnt to stabilize and manipulate this biomolecule and now recent findings are actually transforming mRNA into new drugs category with many therapeutic applications. However, efforts on interdisciplinary biomedical approach are still required to translate the potentially commendable preclinical findings on mRNA therapeutics into the clinic. The conference will be held with the objective to discuss and exchange innovative ideas in the path of messenger RNA-based therapeutics. The presentations include internationally renowned biomedical researchers from the diverse area: vaccination, innovative therapies and delivery systems

Convenors

  • Dr Sohail Akhter, LE STUDIUM RESEARCH FELLOW
    FROM: Pharmaceutical Science at Faculty of Pharmacy, Jamia Hamdard University, New Delhi, India
    IN RESIDENCE AT: Centre de Biophysique Moléculaire (CBM), UPR 4301 (Molecular Biophysics Center, CNRS) Orleans, France
  • Pr Chantal Pichon
    Centre de Biophysique Moléculaire (CBM), UPR 4301 (Molecular Biophysics Center, CNRS) Orleans, France

Confirmed speakers

  • Pr Philippe Barthelemy, Cancéropôle Grand Sud Ouest, équipe Chimie des acides nucléiques, aptamères, sondes et transport - INSERM U 1212 – France
  • Pr Nicolai Bovin, Synthaur LLC - Russia
  • Pr Rebecca Cox, University of Bergen – Norway
  • Dr Mustafa Diken, TrOn-Mainz – Germany
  • Dr Jonathan Finn, Intellia Therapeutics – USA
  • Pr Carlos Alberto Guzman, Department of Vaccinology, Helmholtz Centre for Infection Research – Germany
  • Pr Jacek Jemielity, Laboratory of Bioorganic Chemistry Centre of New Technologies University of Warsaw – Poland
  • Pr Jonathan Heddle, Malopolska Center for biotechnology – Poland
  • Pr Mickael Kormann, University Children's Hospital - Section I Pediatric Infectiology & Immunology Tubingen University" – Germany
  • Dr Ine Lentacker, Laboratory for General Biochemistry and Physical Pharmacy, Ghent University – Belgium
  • Dr Kenneth Mc Cullough, Institute of Virology and Immunology – Switzerland
  • Dr Patrick Midoux, Center of Molecular Biophysics – France
  • Dr Bruno Pitard, In Cell Art – France
  • Dr Philippe Roingeard,  PU-PH Faculty of medicine François Rabelais and University Hospital of Tours – France
  • Pr Nicola Tirelli, University of Manchester - UK
  • Pr Kris Thielemans, Vrije Universiteit Brussel – Belgium
  • Pr Richard Weiss, Austria Department of Molecular Biology, University of Salzburg – Austria

Programme

WEDNESDAY 22ND OF MARCH

  • 08H00 Welcome coffee registration       
  • 08H45 Official opening

KEYNOTE LECTURE

  • 09H00 Pr Kris Thielemans
    Trimix technology for mRNA- based vaccination                

SESSION 1 : UNIVAX EU PROJECT            

  • 09H35 Dr Kenneth McCullough
    Dendritic cells and Self-Amplifying Replicons Vaccines: the Univax consortium​          
  • 10H10 Pr Carlos Guzmán
    Adjuvantation with cyclic-di-nucleotides: an efficacious strategy to tailor humoral and cellular immune responses to vaccination                        
  • 10H40 Coffee break      
  • 11H10 Pr Rebecca Cox  
    Human clinical studies of influenza vaccines.                     
  • 11h40 Oral presentation : Dr Thomas Démoulins 
  • 12H00 Pr Nicolai Bovin
  • 12H30 Pr Nicola Tirelli
  • 13H00 Lunch

SESSION 2 : MRNA STRUCTURE, PRODUCTION AND TRAFFICKING                            

  • 14H00 Pr Jacek Jemielity
    Chemical modifications at 5’ end of mRNA: towards mRNA-based gene therapy.
  • 14H30 Dr Mustafa Diken       
    Systemic delivery of mRNA vaccines for potent cancer immunotherapy.     
  • 15H00 Oral presentation : Lucie Pigeon
  • 15H20 Oral presentation : Rein Verbeke

SESSION 3 : MRNA AS INNOVATIVE THERAPEUTICS 

  • 15H40 Pr Michael Kormann
    Therapeutic application of chemically modified mRNA in mouse models of severe lung diseases        
  • 16H10 Coffee break      
  • 16H40 Pr John Finn        
    Robust In Vivo Gene Editing in Mouse Hepatocytes with Systemic Lipid Nanoparticle Delivery of CRISPR/Cas9 Components                    
  • 17H10 Pr Richard Weiss
    Paving the way for prophylactic allergy gene vaccines –naturally acquired immunity as a template for vaccine design. 
  • 17H40 Oral presentation : Federico Perche
  • 18H30 Public Lecture in french by Pr Philippe Roingeard
    Défi et challenge de la mise au point d’un vaccin contre le virus de l’hépatite C                
  • 20H00 Gala dinner at Le Lift            

THURSDAY 23RD OF MARCH

  • 08H30 Welcome coffee

SESSION 4: MRNA DELIVERY

  • 09H00 Dr Bruno Pitard
    Bioinspired delivery systems for mRNA vaccines and medicines               
  • 09H30 Dr Patrick Midoux
    LPR-based mRNA vaccine delivery systems
  • 10H00 Dr Ine Lentacker
    Ultrasound triggered mRNA delivery to dendritic cells: towards an in vivo cancer vaccination strategy?
  • 10H30 Coffee break
  • 11H00 Pr Philippe Barthélémy 
    Nucleic acid chemistry for nanomedicine
  • 11H30 Pr Jonathan Heddle
    Building Artificial Nanoscale Structures With Proteins 
  • 12H00 Dr Sohail Akhter
  • 12H30 Conclusions and Closing ceremony          
  • 13H00 Lunch
  • 14H30 Guided visit

Main topics

mRNA therapeutics; mRNA expression; mRNA delivery and intracellular trafficking ; mRNA-based vaccination; RNA Replicons technology; adjuvants in vaccine; nucleic acid vectors; synthetic non-viral vectors; dendritic cell targeting. 

Scientific committee

  • Kenneth.Mc Cullough
  • Carlos Gunzmann
  • Chantal Pichon
  • Sohail Akhter
  • Patrick Midoux 

PRICING

Private institutions 250 EUR
Researchers 180 EUR
Students 60 EUR
Gala dinner 60 EUR

Partners of the event