Innate immunity in a biomineralized context: trade-offs or synergies?

Biomineralized structures can function as a barrier to the external environment, and as such are conceptually entwined with innate immune processes. Disentangling immune and biomineralization mechanisms represents a significant challenge for researchers trying to understand how organisms could integrate biomineral formation and plasticity with maintenance of critical innate immune protection. In fact, there is increasing evidence that immune proteins can serve genuine dual-functional roles, both in regulation of biomineralization, as well as resisting pathogens. This awareness is growing in models as diverse as the dual-functionning haemocytes of marine bivalves, and in mineralization / demineralization of the avian eggshell. Moreover, reef corals, in which calcification is coupled to the photosynthetic activity of their mutualistic symbiots, must adapt their innate immune system to achieve this tolerance. Cnidarian immune-related processes in response to abiotic stresses are increasingly implicated in loss of symbiosis and coral bleaching.

This conference aims to bring together scientists working with diverse models of biomineralization, for an exchange of perspectives on the innate immune function of the calcified barrier and the dual role played by specific genes / proteins in these two critical functions.

Key words

biomineralization; barrier; calcium carbonate; anti-microbial; eggshell; mollusk; bivalve; corals; innate immunity

Confirmed speakers

• Dr Liliana D’Alba, University of Gent - BE
• Dr Sophie Berland, BOREA / CNRS, Caen Normandy University - FR
• Dr Claudine Blin, LP2M /CNRS, Nice Côte d'Azur University - FR
• Prof. Rafael Da Rosa, LIAA, Federal University of Santa Catarina - BR
• Prof. Isabelle Domart-Coulon, MCAM / CNRS, National Museum of Natural History - FR
• Dr Joël Gautron, BOA / Centre INRAE Val de Loire, University of Tours - FR
• Dr Nicolas Guyot, BOA / Centre INRAE Val de Loire, University of Tours - FR
• Prof. Bernd Kaspers, Ludwig Maximilian University of Munich - DE
• Prof. Marc McKee, McGill University - CA
• Dr Caroline Palmer, University of Plymouth - UK
• Prof. Alejandro Rodriguez Navarro, University of Granada - ES
• Dr Aline Tribollet, IPSL-LOCEAN, Pierre and Marie Currie University - FR
• Dr Jeroen Van de Water, Monaco Scientifique Centre - MC

ORAL PRESENTATIONS & POSTERS

Abstracts for oral presentation and posters should be submitted before Friday 6th March 2020. Please upload your abstract during the registration or send it before the deadline to maurine.villiers@lestudium-ias.fr.

The number of oral presentations is limited, convenors will process a selection and confirm your presentation not later than Tuesday 10th March 2020.
Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes, portrait format.

Please download the template for oral presentation.
Please download the template for poster presentation.

Location

Hôtel de Ville : Boulevard Heurteloup - 37000 TOURS - FR

The event will take place in the city centre at the Hotel de Ville of Tours located Square Jean-Jaures and very near the main train station. This elegant building was designed in the early 20th century by Victor Laloux, the architect of the Gare d'Orsay in Paris (now the Musée d'Orsay).  Its monumental stairs, paintings and sculptures make it a recommended place to visit. Participants will also have the opportunity to discover French cuisine and Loire Valley wines during an evening social.

PRACTICAL INFORMATION

• List of recommended Hotels in Tours

PRELIMINARY PROGRAMME

TUESDAY MARCH 31^st 2020

• 12:30    Welcome lunch and registration
• 14:00    Official opening
  Sophie Gabillet - Introduction: Le Studium
  Prof. Max Hincke & Dr Sophie Rehault-Godbert - Introduction: Dynamics of Structural Barriers and Innate Immune Components

SESSION 1: OVERVIEW OF INNATE IMMUNITY IN BIOMINERALIZED ORGANISMS

• 14:30    Prof. Marc McKee - The structure of avian (chicken) eggshell
• 15:15    Prof. Rafael Da Rosa - New insights into oyster antimicrobial defense: Cellular, molecular and genetic view
• 16:00    Coffee break / poster viewing
• 16:30    Dr Caroline Palmer - Immunity and the coral crisis
• 17:15    Dr Claudine Blin - The innate immune function and diversity of osteoclasts
• 18:30    Public lecture in French: Dr Joel Gautron - L’œuf dans tous ses états
• 20:00    Wine and cheese cocktail - Hôtel de ville

WEDNESDAY APRIL 1^st 2020

• 08:30    Welcome coffee

SESSION 2: AVIAN EGGS: STRUCTURE, MICROBIOTA AND MOLECULES OF INNATE IMMUNITY

• 09:00    Dr Sophie Réhault-Godbert - The eggshell microbiome is the first level of egg defense
• 09:30    Dr Liliana D’Alba - Eggshell mineralization in relation to nesting ecology in reptiles
• 10:00    Prof. Alejandro Rodriquez-Navarro - Mechanisms of eggshell biomineralization
• 10:30    Coffee break / Poster viewing
• 11:00    Dr Nicolas Guyot - Phylogenetic and structural evolution of egg antimicrobial proteins and peptides
• 11:30    Prof. Bernd Kaspers - The developing immune system of the chicken embryo
• 12:00    Prof. Maxwell Hincke - The chroriallantoic membrane: a dynamic structure at the interface of the biomineralized eggshell and components of innate immunity
• 12:30    Lunch

SESSION 3: THEME MARINE INVERTEBRATES (CORALS, BIVALVES)

• 14:00    Prof. Isabelle Domart-Coulon - Coral immune cells and skeleton production during early life stages interactions with benthic biofilms
• 14:30    Dr Aline Tribollet - Microbes in coral skeletons : their diversity, roles and adaptations to a changing environment
• 15:00    Coffee break / Poster viewing
• 15:30    Dr Jeroen Van De Water - Host-microbe interactions in octocoral holobionts
• 16:00    Dr Sophie Berland - Utmost commitment of shell matrix proteins to endow bivalve mollusc shells with both adaptive mechanical properties and biochemical defense
• 16:30    Dr Natalie Reznikov - Application of Convolutional Neural Networks (CNN – deep learning) for processing and analysis of 3D images in biomineralization research – examples from bone, coral and egg
• 18:00    Guided visit of the historical center of Tours
• 19:30    Gala dinner

THURSDAY APRIL 2^nd 2020

• 08:45    Welcome coffee

SESSION 4:

• 09:00    Lilian Stapane - Extracellular vesicle - mediated mineralization
• 09:20    To Be Determined.
• 09:40    To Be Determined.
• 10:00    Short Oral Poster Presentations (3-minute talk-1slide)
• 10:30    Coffee break
• 11:00    Dr Joel Gautron - Integrative workshop session: Lessons learned and the path forward for innate immunity in biomineralization
• 12:00    Concluding remarks, poster remarks and lunch box distribution

PRICING

(Including two lunches, a wine & cheese cocktail and the coffee breaks)