January 28, 2019 - January 30, 2019

Induced Pluripotent Stem Cells (iPSCs): From Disease Models to Mini-Organs

Induced pluripotent stem cells (iPSCs) are pluripotent cells obtained by the development of a technique of reprogrammation of somatic cells using 4 defined factors. Such spectacular feature deserved the Nobel Prize in Physiology or Medicine in 2012. iPSCs have provoked a true revolution in the fields of Biological Sciences and Medicine. Scientists started to being able to access neurons derived from somatic cells (i.e. skin fibroblasts) of patients with neurological illnesses such as Alzheimer’s and Parkinson’s and use it as models for research laboratory studies. iPSCs opened new avenues for a better understanding about human cell differentiation, and for the ex vivo development of human organs. Besides, iPSCs brought new hopes for the development of cell therapies for conditions such as blindness and liver and kidney diseases. More recently, Scientists could obtain «mini-organs» from iPSCs. These three-dimensional structures mimic human organs, allowing a unique opportunity to access whole organs affected in different pathologies. Moreover, iPSCs derived from patients with the most diverse diseases are a highly attractive tool for screenings selecting new medicines from libraries with thousands of compounds.

In this conference the most prominent experts from the iPSCs field will discuss the different applications, advantages, and caveats of the use of iPSCs in Biological Sciences and Medicine. We will cover five main themes, namely: (1) iPSCs reprogrammation and differentiation, (2) iPSCs disease models, (3) iPSCs in drug discovery, (4) iPSCs in cell therapies, and (5) organoids (or «mini-organs») derived from iPSCs. 

This international conference is organised in the framework of the ARD 2020 Biopharmaceuticals Programme.

Convenors

  • Dr Denis Reis de Assis, LE STUDIUM Research Fellow / ARD 2020-BIOPHARMACEUTICALS Programme
    FROM: Brain Institute of PUCRS - BR
    IN RESIDENCE AT: Imaging and Brain laboratory (iBrain), UMR 1253, INSERM / University of Tours - FR
  • Prof. Hélène Blasco,
    Imaging and Brain laboratory (iBrain), UMR 1253, INSERM / University of Tours - FR

Scientific comittee

  • Prof. Christine Baldeschi - I-Stem Institute for Stem Cell Therapy and Exploration of Monogenice diseases - FR
  • Prof. Alexandra Benchoua, Institute for Stem Cell Therapy and Exploration of Monogenice Diseases (I-Stem) - FR 
  • Dr Alessandro Prigione - Max-Delbrück-Centrum für Molekulare Medizin (MDC), Helmholtz Association - DE
  • Dr Jerome Jullien - Wellcome Trust/Cancer Research UK Gurdon Institute -  UK
  • Dr Delphine Bohl - Brain & Spine Institute - FR
  • Dr Jerome Mertens - Salk Institute - USA
  • Prof. Jari Koistinaho - Neuroscience Center, University of Helsinki - FI
  • Dr Denis Reis de Assis - Brain Institute of PUCRS - BR / Imaging and Brain laboratory (iBrain), UMR 1253, INSERM / University of Tours - FR

Confirmed speakers

Oral presentations & posters

Abstracts for oral presentation and poster should be submitted before Monday 17th of December 2018. Please upload your abstract during the registration or send it before the deadline to maurine.villiers@lestudium-ias.fr.

The number of oral presentations is limited, convenors will process a selection and confirm your presentation not later than Friday 21st of December 2018.
Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes, portrait format.

Please download the template for oral presentation.
Please download the template for poster presentation.

Location

CCI Touraine : 4 bis, rue Jules Favre - 37000 TOURS - FR

The event will take place at the Palais du Commerce of Tours, built between 1757 and 1759 by the Merchants of Tours for their jurisdiction and business, in the heart of the city. The Palais de Commerce is a luxurious, sober and elegant private mansion built in Bourré stones. Its western side faces the Renaissance remains of the former Beaune-Semblançay hotel, the unfortunate silversmith of François the First. Located between the Hôtel de Ville and La Loire river, the Palais de Commerce is also a stone's throw from the Museum of Fine Arts in Tours.

Preliminary programme

Monday January 28th 2019

  • 12:30    Welcome lunch & registration
  • 14:00    Official Opening
  • 14:15-18:00    Sessions 1 & 2

​​Session 1: Cell Reprogrammation

  • Dr Jérome Jullien

​​Session 2: Metabolism and Ion Channels in Cancer

    • Dr Jean-François Dumas - Role of cardiolipin metabolism in cancer
    • Dr Sébastien Roger - Role of P2X7 receptor in cancer cell invasiveness, mammary tumour growth and metastatic progression

    Tuesday January 29th 2019

    • 09:00    Welcome coffee

    Session 3: Neurological Disease Models

    • Prof. Ludo Van Den Bosch
    • Prof. Patrick Vourc'h
    • Prof. Alexandra Benchoua
    • Prof. Frédéric Laumonnier
    • Dr Alessandro Prigione - iPSC modeling of mitochondrial diseases
    • Dr Delphine Bohl - Motor neuron intrinsic defects and contribution of myeloid cells to neurodegeneration in ALS with human iPS-derived cells
    • Prof. Jari Koistinaho - Modelling brain diseases with iPSC-derived cells
    • Dr Jerome Mertens
    • Prof. Cécile Martinat
    • 18:30    Public Lecture in French : Prof. Christian Andres

    Wednesday January 30th 2019

    • 09:00    Welcome coffee
    • 09:30-12:00    Session 4

    Session 4: Mini-Organs and Skin Disease Models

    • Prof. Christine Baldeschi - Production of clinical grade temporary epidermal substitute obtained from hESC derived keratinocytes for the treatment of sickle cell leg ulcers: a challenge for regenerative medicine
    • Dr Olivier Goureau - Human iPS cell-derived retinal organoids: from development to disease
    • 12:00    Conclusion

    PRICING

    (Including two lunches, a Wine & Cheese cocktail and the coffee breaks)

    Private institutions 250 EUR
    Public institutions 180 EUR
    Students & PhD Scholars 75 EUR
    Gala dinner 60 EUR

    Partners of the event