Gonadotropins in the Physiopathology: Current advances in the Mechanisms of Action
Virtual meeting: instructions to connect are communicated upon registration.
Human reproductive health and fertility is dependent on gonadotropins (FSH &LH), which act through their specific G protein-coupled receptors (GPCR) and regulate the reproductive functions. Gonadotropin hormone imbalance may contribute to the development of sub-fertility or infertility such as seen in women with polycystic ovary syndrome (PCOS), the most common endocrinopathy and a threat to human reproduction. The usage of ART/IVF has increased all over the world to restore sub-fertility in young women.
With the emerging role of gonadotropins (FSH and LH), It is important to understand the mechanisms of gonadotropin signaling, especially for delineating the metabolic defects due to their imbalance (high LH:FSH ratio) in women with PCOS, menopause and gynaecological cancers. It is further imperative to increase the positive outcome of IVF protocols to deal with the sub-fertility in young women due to PCOS or other environmental factors.
This interdisciplinary conference will discuss the current challenges in the targeting of GPCRs and finding novel pathways to optimize not only reproduction but also metabolism, and to discuss their role as non-gonadal ligands.
This international conference is organised in the framework of the ARD CVL BIOPHARMACEUTICALS Programme.
- Gonadotropin Signaling
- G protein-coupled receptors
- Prof. Rita Singh, LE STUDIUM Visiting Researcher
FROM: University of Delhi - IN
IN RESIDENCE AT: Physiology of Reproduction and Behaviour (PRC) / Centre INRAe Val de Loire, CNRS, University of Tours, IFCE - FR
- Dr Pascale Crépieux,
Physiology of Reproduction and Behaviour (PRC) / Centre INRAe Val de Loire, CNRS, University of Tours, IFCE - FR
- Prof. George Bousfield, Wichita State University - USA
- Prof. Livio Casarini, University of Modena and Reggio Emilia - IT
- Dr Pascale Crépieux , Physiology of Reproduction and Behaviour (PRC) / Centre INRAe Val de Loire, CNRS, University of Tours, IFCE - FR
- Prof. John S. Davis, University of Nebraska Medical Center & Omaha VA Medical Center - USA
- Dr Joëlle Dupont, Department of Animal Physiology and Livestock Systems, Centre INRAe Val de Loire, CNRS, University of Tours - FR
- Prof. Stephen Franks, Imperial College London, UK
- Dr Aylin Hanyaloglu, Imperial College London - UK
- Prof. Rajendra Kumar, Anschutz Medical Campus - USA
- Prof. Rita Singh, University of Delhi - IN
- Prof. Jerome Strauss, University of Pennsylvania - USA
- Prof. Alfredo Ulloa Aguirre, National Autonomous University of Mexico - MX
Please download the template for oral presentation.
DAY 1: Wednesday September 14th, 2022 (Paris Time, GMT +2)
- 12:00 Welcome address: Rita Singh
- 12:10 Sophie Gabillet, General Secretary of Le Studium
- 12:15 Remarks by Yves-Michel Ginot, President of Le Studium
Session I: Metabolism and reproduction
Chairman: Jerome Strauss
- 12:30 Steve Franks - Metabolic regulation of gonadotropin action in polycystic ovary syndrome (PCOS)
- 13:15 Rita Singh - Cross-talk between FSH and LH: Implications for metabolic disorder in women with PCOS
- 14:00 Joëlle Dupont - Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells
- 14:45 Antara Banerjee - Functional Characterization of two naturally occurring mutations V221G and T449N in the follicle stimulating hormone receptor
- 14:55 Romain Yvinec - Kinetic biased signaling: towards a system biology definition of drugs selectivity. Illustration on the Follicle Stimulating Hormone Receptor
- 15:05 Anjali Geethadevi - Impaired crosstalk between FSH and IRS-2 alters glucose metabolism in granulosa cells- Implications in PCOS pathogenesis.
- 15:15 Emilia Przygrodzka - LH-responsive metabolic pathways essential for luteal steroidogenesis
15:30 Coffee break
Session II: Gonadotropin in physiopathology
Chairwoman: Joëlle Dupont
- 16:00 Jerry Strauss - A novel signal transduction pathway directs increased thecal cell androgen production in polycystic ovary syndrome
- 16.45 Kim Jonas - Towards understanding the role of gonadotrophin receptor oligomerisation in reproductive health and disease
- 17:30 Rajendra Kumar - Genetic and pharmacological approaches to study FSH action in the male
- 18:15 Quick round up of the day
DAY 2: Thursday September 15th, 2022 (Paris Time, GMT +2)
12:15 Welcome address
Session III: Functional and physical gonadotropin receptor interaction
Chairman: Eric Reiter
- 12:30 Aylin Hanyaloglu - Spatial control of gonadotrophin hormone receptor signaling; mechanisms and applications
- 13:15 Pascale Crépieux - Regulation of the translatome by FSH, in Sertoli cells
- 14:00 Livio Casarini - Crosstalk between G protein-coupled estrogen and gonadotropin receptors
- 14:45 Juliette Gourdon - Role of cellular compartmentation of gonadotropin receptors’ signalling in reproductive physiology
- 14:55 Clara Lazzaretti - Effects of human luteinizing hormone/choriogonadotropin receptor (LHCGR) and G protein-coupled estrogen receptor (GPER) heteromers in vitro.
- 15:05 Elisa Mascolo - Impact of two differently glycosylated recombinant FSH on signal transduction.
- 15:15 Elia Paradiso - Luteinizing hormone (LH)- and choriogonadotropin (hCG)-induced internalization of the receptor (LHCGR) is responsible for hormone-specific signaling
- 15:30 Coffee break
Session IV: Regulation of gonadotropin action
Chairmen: Smita Mahale & Rajan Dighe
- 16:00 George Bousfield - Estradiol and progesterone effects on transfected rat somatotroph GH3 cell N-glycosylation of recombinant hFSH.
- 16:45 Alfredo Ulloa-Aguirre - Mutations in gonadotropin receptors that impact receptor trafficking and reproductive function. Functional rescue by pharmacological chaperones
- 17:30 John S. Davis - Hypo-glycosylated hFSH has greater bioactivity than fully-glycosylated hFSH enabling greater follicular health and growth
- 18:15 Pascale Crépieux - Concluding remarks on the Conference
- 18:30 Rita Singh - Declaration of Awards - Vote of Thanks