March 26, 2018 - March 28, 2018

Neurotransmitters: non-neuronal functions and therapeutic opportunities

The registration is closed

Neurotransmitters have profound effects throughout the body, and are essential for communication between neurons, stimulation of muscle and the function of epithelial layers. It is now clear that neurotransmitters regulate a wider range of physiological responses than previously appreciated, including major influences on the immune system, and can be produced by non-neuronal sources.

In this meeting we will present new insights into how neurotransmitters function outside of the nervous system, how these roles contribute to protecting the body from disease and how these molecules can be manipulated to treat disease.


  • Dr William Horsnell, LE STUDIUM / Marie Skłodowska-Curie Research Fellow.
    FROM: The Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town - ZA and Institute of Microbiology and Infection (IMI), University of Birmingham - UK
    IN RESIDENCE AT: Experimental and Molecular Immunology and Neurogenetics (INEM) / CNRS, University of Orléans - FR
  • Dr Bernhard Ryffel,
    Experimental and Molecular Immunology and Neurogenetics (INEM) / CNRS, University of Orléans - FR


Neurotransmitters: non-neuronal functions and therapeutic opportunities

Main Topics

Neurotransmitters, epithelial cells, immune system, nervous system, lung health, mucosal immunity, infection

Confirmed Speakers


  • Pr Reinoud Gosens, University of Groningen – NL
  • Dr William Horsnell, Experimental and Molecular Immunology and Neurogenetics (INEM) / CNRS, University of Orléans - FR
  • Dr Bernhard Ryffel, Experimental and Molecular Immunology and Neurogenetics (INEM) / CNRS, University of Orléans - FR
  • Pr Murray Selkirk, Imperial College London – UK

Oral presentations & Posters

Abstracts for oral presentation should be submitted before Friday 16th of February. The number of oral presentations is limited, convenors will process a selection and confirm your presentation not later than Friday 16th of February.

Please send your poster (or the abstract of your poster) to Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes. 


Hôtel Dupanloup, 1 rue Dupanloup 45000 Orléans

The conference venue is unique. Located right next to the Orléans’ cathedral, the episcopal palace of Orléans, built between 1635 and 1641, locally known as the Hôtel Dupanloup, is a classical French building which served until 1905 of residence to the bishops of Orléans.  Since 2014, the renewed palace hosts the International University Center for Research and Le Studium Loire Valley Institute for Advanced Studies.

Participants will be welcomed in this exceptional surrounding, blending Middle Age and Renaissance cultures with modern design and will have the opportunity to discover French cuisine and wines.


Conference PROGRAM

Monday March 26th 2018

  • 12:30    Welcome lunch & registration
  • 14:00    Official Opening, William Horsnell, Sophie Gabillet (Le Studium), Ioan Todinca (VP Research University of Orléans)
  • 14:30    Dr Daniel Mucida - Microbe-mediated inhibition of gut sympathetic innervation
  • 15:10    Dr Phillipe Jay - Intestinal epithelial tuft cells: sentinels of the gut mucosa
  • 15:40    Coffee break & Posters Session
  • 16:20    Pr Wolfgang Kummer - Non-neuronal acetylcholine links pathogen detection by taste receptors to avoidance reflexes and cilia-drive mucociliary clearance
  • 17:00    Dr Denise Fonseca - Non-classical role of cholinergic pathway in the induction of allergic type 2 inflammation
  • 17:15    Dr Dieudonnée Togbe - PKC- θ: the missing kinase for ILC2 activation
  • 18:30    LE STUDIUM Lecture - Pr Stéphane Mortaud - Pesticides et système nerveux : des interactions suspectes
  • 20:00    Wine & Cheese Cocktail

Tuesday March 27th 2018

  • 08:30    Welcome coffee
  • 09:00    Dr Sophie Ugolini - Neuroendocrine regulation of immunity
  • 09:30    Pr Wouter De Jonge - Neuronal and non-neuronal regulation of intestinal host defense
  • 10:00    Coffee break
  • 10:30    Pr Rick Maizels - Immunity to intestinal helminth parasites
  • 11:10    Pr Murray Selkirk - Nematode acetylcholinesterases and cholinergic regulation of immunity
  • 11:40    Dr William Horsnell - Protease mediated lung damage and cholinergic signaling
  • 12:10    Anna Lena Neumann - Contribution of acetylcholine in regulating immunity to Litomosoides sigmodontis infection
  • 12:25    Lunch
  • 14:00    Pr Reinoud Gosens - Acetylcholine beyond bronchoconstriction: roles in pulomonary inflammation and remodeling
  • 14:30    Dr Vincent Feuillet - Influence of adrenergic signals and β-blockers on the efficiency of anti-tumor immune responses
  • 15:00    Pr Veronika Grau - Cholinergic control of IL-1β maturation in human monocytic cells
  • 15:30    Coffee break
  • 16:00    Dr Valérie Quesniaux - IL-33/ST2 pathway in cerebral malaria and cognition
  • 16:30    Dr Sylvie Berrard - Opening the neuronal cholinergic system to its diverse roles out of the brain
  • 17:00    Dr Madeleine Erard-Garcia - Systemic effects of the long noncoding RNA COSMOC in autism spectrum disorders
  • 17:45    Guided visit
  • 19:30    Social dinner - Le Lift

Wednesday March 28th 2018

  • 08:30    Welcome coffee
  • 09:00    Pr Sergei Grando - THE NON-NEURONAL EFFECTS OF BOTULINUM TOXIN: A novel paradigm of treating human disease with deadly neurotoxins
  • 09:30    Dr Katrin Richter - C-reactive protein – an unconventional agonist of nicotinic acetylcholine receptors that controls ATP-mediated maturation of monocytic interleukin-1β
  • 09:45    Dr Matthew Darby - Manipulating acetylcholine (ACh) to control respiratory viral infections and pathological pulmonary immune responses
  • 10:00    Pr Klaus Erb - Anti-inflammatory effects of tiotropium in mouse models of COPD exacerbations
  • 10:40    Coffee break
  • 11:10    Pr Valentin Pavlov - Neuromodulation for therapeutic benefit in inflammatory diseases: from basic research
    to clinical trials


Including two lunches, a Wine & Cheese Cocktail and the coffee breaks

Private institutions 250 EUR
Public Institutions 180 EUR
Students 75 EUR
Social dinner 60 EUR

Partners of the event