Challenges and prospects in chemoselective ligations: from protein synthesis to site-specific conjugation
The conference will start on Monday 27th January at 12:30 and end on Wednesday 29th at noon.
Recent years have seen an exponentially growing interest in chemical reactions enabling the selective modification of proteins and peptides. These advances are intimately linked to the development of methodologies for protein engineering with an atomic precision, for the generation of well-defined antibody-drug conjugates or on-demand probes to decipher biological processes. Such chemoselective reactions are also widely utilized for the total synthesis and semi-synthesis of proteins through chemical ligation of unprotected peptide fragments, an approach highly complementary to recombinant production. The chemical reactions implemented for both purposes share the same requirements: compatibility with dilute aqueous solution at physiological pH, and tolerance to the myriad functional groups commonly found in biomolecules. These remarkable features inspired the advent of biorthogonal reactions, which can be carried out in living systems.
This international conference is jointly organized by LE STUDIUM Loire Valley Institute for Advanced Studies and the Centre for Molecular Biophysics - CNRS Orléans. This event will be held under the auspices of the French Peptide Society (GFPP) and follows three previous editions (Paris 2001, Lille 2008 and 2016) of short international meetings dedicated to chemical ligation.
Dr Vincent Aucagne,
Center for Molecular Biophysics (CBM) / CNRS - FR
Dr Lutz Ackermann, Institute of Organic and Biomolecular Chemistry / Georg-August-University of Göttingen - DE
Dr Didier Boturyn, Department of Molecular Chemistry / University of Grenoble - FR
Dr Fabienne Burlina, Biomolecules Laboratory / Sorbonne University, Paris - FR
Prof. Alexander Dömling, Faculty of Pharmacy / University of Groningen - NL
Prof. Beat Fierz, Federal Polytechnic School of Lausanne - CH
Prof. Matthew B. Francis, Department of Chemistry / University of California, Berkeley - US
Dr Lei Liu, Department of Chemistry / Tsinghua University
Dr Oleg Melnyk, Biology Institute of Lille / Pasteur Institute of Lille - FR
Dr Cyrille Sabot, COBRA Laboratory / Normandy University, Rouen - FR
Dr Olivier Sénèque, Chemistry and Biology of Metals laboratory / CEA Grenoble - FR
Dr Frédéric Taran, Molecular labeling and bio-organic chemistry unit, CEA Saclay - FR
Dr Alesia Tietze, Department of Chemistry and Molecular Biology / University of Gothenburg, Göteborg - SE
Dr Vladimir Torbeev, Institute of Supramolecular Science and Engineering / University of Strasbourg - FR
Prof. Carlo Unverzagt, Department of Chemistry / Universität Bayreuth - DE
Dr Birgit Wiltschi, Synthetic Biology Group / ACIB – Austrian Centre of Industrial Biotechnology, Graz - AT
Oral presentations & posters
Abstracts for oral presentation should be submitted before Monday 18th November 2019 and before Monday 02nd December 2019 for poster. Please upload your abstract during the registration or send it before the deadline to email@example.com.
The number of oral presentations is limited, convenors will process a selection and confirm your presentation not later than Friday 22nd November 2019.
Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes, portrait format.
The conference venue is unique. Located right next to the Orléans’ cathedral, the episcopal palace of Orléans, built between 1635 and 1641, locally known as the Hôtel Dupanloup, is a classical French building which served until 1905 of residence to the bishops of Orléans. Since 2014, the renewed palace hosts the International University Center for Research and Le Studium Loire Valley Institute for Advanced Studies.
Participants will be welcomed in this exceptional surrounding, blending Middle Age and Renaissance cultures with modern design and will have the opportunity to discover French cuisine and wines.
(Including two lunches, a Wine & Cheese cocktail and the coffee breaks)
|Private institutions||250 EUR|
|Public institutions||180 EUR|
|Students & PhD Scholars||75 EUR|
|Social dinner||60 EUR|